Prognostic significance of cyclooxygenase-2 (COX-2) and expression of cell cycle inhibitors p21 and p27 in human pleural malignant mesothelioma
Prognostic significance of cyclooxygenase-2 (COX-2) and expression of cell cycle inhibitors p21 and p27 in human pleural malignant mesothelioma
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DOI：
10.1136/thx.2003.008912
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发表时间：
2004-05-01
期刊：
影响因子：
10
通讯作者：
Scarpa, S
中科院分区：
文献类型：
--
作者：
Baldi, A;Santini, D;Scarpa, S
背景资料：对29例恶性间皮瘤组织中考克斯-2和p27的表达进行了分析，并对考克斯-2和p27的表达与恶性间皮瘤的预后进行了研究。结果：p27和p21表达之间存在显著正相关（p< 0.0001），但考克斯-2表达与p27（p = 0.001）和p21（p <0.0001）均呈负相关。p53与所有其他免疫组化参数之间无统计学显著相关性。单因素分析显示p21、p27和考克斯-2表达对总生存期有显著影响，但多因素考克斯回归分析显示影响总生存期的唯一免疫组化参数是考克斯-2。结论：考克斯-2表达可能是间皮瘤的一个有用的预后指标。
Background: A study was undertaken to analyse the potential prognostic value of the immunohistochemical expression of cyclooxygenase-2 (COX-2) and p27 in 29 malignant mesotheliomas already screened for the expression of p21 and p53.Methods: Immunohistochemistry was used to determine the expression of COX-2 and p27. The correlation with survival of these factors and of p21 and p53 expression was assessed by univariate and multivariate analyses.Results: A positive statistically significant correlation was found between p27 and p21 expression (p< 0.0001), but there was a negative correlation between COX-2 expression and both p27 ( p = 0.001) and p21 ( p, 0.0001). No statistically significant correlation was recorded between p53 and all the other immunohistochemical parameters. Univariate analysis showed that overall survival was strongly influenced by p21, p27, and COX-2 expression, but multivariate Cox regression analysis showed that the only immunohistochemical parameter to influence overall survival of patients with mesothelioma was COX-2.Conclusions: These findings suggest that COX-2 expression may be a useful prognostic parameter for mesothelioma.