FORELIMB MOTOR-PERFORMANCE FOLLOWING DORSAL COLUMN, DORSOLATERAL FUNICULI, OR VENTROLATERAL FUNICULI LESIONS OF THE CERVICAL SPINAL-CORD IN THE RAT
FORELIMB MOTOR-PERFORMANCE FOLLOWING DORSAL COLUMN, DORSOLATERAL FUNICULI, OR VENTROLATERAL FUNICULI LESIONS OF THE CERVICAL SPINAL-CORD IN THE RAT
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DOI：
10.1006/exnr.1993.1060
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发表时间：
1993-04-01
影响因子：
5.3
通讯作者：
REIER, PJ
中科院分区：
文献类型：
--
作者：
SCHRIMSHER, GW;REIER, PJ
研究了大鼠脊髓损伤后前肢运动控制的神经解剖学基础。在脊髓c4水平行局灶性脊髓切断术，以确定背柱、背外侧索窝和腹外侧索窝的长束通路损伤对前肢到达和颗粒回收任务的影响。背柱损伤并没有显著降低抓取性能，但确实会产生：(1)抓握过程中手指使用的定性改变，(2)在抓取过程中定位错误，(3)明显缺乏感知爪中颗粒存在的能力。背外侧索的损伤在损伤后的所有时间间隔内，由于手指屈曲受损导致明显的抓握缺陷，导致颗粒回收能力明显下降。腹外索的损伤不会造成持续的、显著的检索能力下降，尽管表现出以轻微的前肢达到低垂和过早抓取为特征的定性缺陷。通过与以往大鼠的椎骨上和周围病变研究以及其他哺乳动物的椎骨上和脊柱病变研究的比较，目前的研究结果表明，大鼠前肢下行和上行脊髓长束运动控制的组织与包括灵长类动物在内的其他哺乳动物非常相似。此外，这些结果表明，大鼠可以作为颈脊髓损伤后行为障碍和恢复的生物医学相关模型。
The neuroanatomical basis of forelimb motor control was examined following various surgical spinal cord lesions in the rat. Focal myelotomies were made at spinal level C4to determine the effects that damage to long-tract pathways in the dorsal columns, dorsolateral funiculi, and ventrolateral funiculi have on a forelimb reaching and pellet retrieval task. Dorsal column lesions did not significantly reduce retrieval performance but did yield: (i) qualitative alterations in digit use during grasp execution, (ii) targeting errors during reaching attempts, and (iii) an apparent lack of ability to sense the presence of a pellet in the paw. Damage to the dorsolateral funiculi produced significantly diminished pellet retrieval performance at all postlesion intervals due to a prominent grasp deficit involving impaired digit flexion. Lesions of the ventrolateral funiculi did not produce a sustained, significant reduction in retrieval performance, although a qualitative deficit characterized by a mild forelimb reaching hypometria and premature grasp execution was exhibited. Based on comparisons with previous supraspinal and peripheral lesion studies in rats and supraspinal and spinal lesion studies in other mammalian species, the current results indicate that organization of descending and ascending spinal long-tract motor control of the forelimb in the rat is very similar to that described in other mammals, including primates. Additionally, these results demonstrate that the rat can serve as a biomedically relevant model of behavioral impairment and recovery following cervical spinal cord injury.