SNPs in CAST are associated with Parkinson disease: a confirmation study.

SNPs in CAST are associated with Parkinson disease: a confirmation study.
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DOI:
10.1002/ajmg.b.31061
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发表时间:
2010-06-05
影响因子:
2.8
通讯作者:
Satten, Glen A.
Satten, Glen A.
中科院分区:
医学3区
文献类型:
--
作者:
Allen, Andrew S.;Satten, Glen A.

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Using data from the National Institutes of Neurological disease and Stroke's (NINDS) study of Parkinson disease (PD), we recently reported that single nucleotide polymorphisms (SNPs) in a region containing the Calpastatin (CAST) gene were associated with PD. Here we follow up this finding with an analysis of the Center for Inherited Disease Research's (CIDR) genome-wide association study in familial PD. After adjusting for population stratification and multiple testing, we find a significant association (p=0.0167) between PD and SNP rs1559085 in CAST. These findings confirm CAST/PD associations in a second, independent, dataset and suggest that CAST be prioritized for further investigation.
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