The Paired Associates Learning (PAL) Test: 30 Years of CANTAB Translational Neuroscience from Laboratory to Bedside in Dementia Research
The Paired Associates Learning (PAL) Test: 30 Years of CANTAB Translational Neuroscience from Laboratory to Bedside in Dementia Research
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DOI：
10.1007/7854_2015_5001
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发表时间：
2016-01-01
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影响因子：
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通讯作者：
Robbins, Trevor W.
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文献类型：
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作者：
Barnett, Jennifer H.;Blackwell, Andrew D.;Robbins, Trevor W.
本文综述了剑桥神经心理学自动成套测验（CANTAB）作为一种适用于人类神经心理药理学研究的跨物种翻译工具的起源和基本原理。我们专注于其用于早期评估和检测阿尔茨海默病，特别是配对协会学习（PAL）测试。我们认为它的心理测量特性，神经验证和效用，包括对健康志愿者，轻度认知障碍（MCI）患者和阿尔茨海默病的大样本研究。我们展示了它如何可以应用于跨物种的研究，使用实验动物来弥合跨物种翻译的“差距”。我们还展示了CANTAB PAL如何通过应用iPad技术在初级保健诊所早期检测记忆问题来弥合第二个翻译“差距”。
The origins and rationale of the Cambridge Neuropsychological Test Automated Battery (CANTAB) as a cross-species translational instrument suitable for use in human neuropsychopharmacological studies are reviewed. We focus on its use for the early assessment and detection of Alzheimer's disease, in particular the Paired Associates Learning (PAL) test. We consider its psychometric properties, neural validation, and utility, including studies on large samples of healthy volunteers, patients with mild cognitive impairment (MCI), and Alzheimer's disease. We demonstrate how it can be applied in cross-species studies using experimental animals to bridge the cross-species translational 'gap'. We also show how the CANTAB PAL has bridged a second translational 'gap' through its application to the early detection of memory problems in primary care clinics, using iPad technology.