Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk.
Age-Related Changes in Glucose Metabolism, Hyperglycemia, and Cardiovascular Risk.
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DOI：
10.1161/circresaha.118.312806
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发表时间：
2018-09-14
影响因子：
20.1
通讯作者：
Ferrucci L
中科院分区：
文献类型：
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作者：
Chia CW;Egan JM;Ferrucci L
衰老和糖尿病是心血管疾病（CVD）的两个众所周知的危险因素。在过去的50年里，预期寿命急剧增加，同时老年人口中糖尿病的流行率也在增加。鉴于CVD风险与衰老和糖尿病相关，大量老年糖尿病患者存在问题。在这篇综述中，我们总结了与糖尿病和心血管疾病有关的流行病学数据，重点是老龄化人口。然后，我们提出的数据高血糖作为心血管疾病的危险因素，并审查目前的知识与年龄相关的糖代谢的变化。接下来，我们回顾了肥胖在年龄相关性血糖失调发病机制中的作用，随后总结了主要随机对照试验的结果，这些试验侧重于通过血糖控制降低心血管风险，特别强调老年人。然后，我们得出结论，我们提出的老化模型，身体成分的变化和胰岛素抵抗可能导致肥胖和糖尿病的生理途径失调-这两种形式的加速老化-和心血管疾病的风险。
Aging and diabetes are two well known risk factors for cardiovascular disease (CVD). Over the past 50 years there has been an dramatic increase in life expectancy with a simultaneous increase in the prevalence of diabetes in the older population. This large number of older individuals with diabetes is problematic, given that CVD risk associated with aging and diabetes. In this review, we summarize epidemiological data relating to diabetes and CVD, with an emphasis on the aging population. We then present data on hyperglycemia as a risk factor for CVD and review the current knowledge of age-related changes in glucose metabolism. Next, we review the role of obesity in the pathogenesis of age-related glucose dysregulation, followed by a summary of the results from major randomized controlled trials that focus on cardiovascular risk reduction through glycemic control, with a special emphasis on older adults. We then conclude with our proposed model of aging, that body composition changes and insulin resistance link possible dysregulation of physiological pathways leading to obesity and diabetes—both forms of accelerated aging—and risks for CVD.