Premature menopause increases cardiovascular risk
Premature menopause increases cardiovascular risk
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DOI：
10.1080/13697130903013452
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发表时间：
2009-01-01
期刊：
影响因子：
2.8
通讯作者：
Archer, D. F.
中科院分区：
文献类型：
--
作者：
Archer, D. F.
年轻女性过早绝经和双侧卵巢切除与心血管疾病、心肌梗死和总死亡率的增加有关。观察性研究表明，卵巢功能丧失与心血管疾病风险增加之间的间隔为5-10年。这一发现与已发表的对接受双侧卵巢切除术的妇女的尸检研究一致。在非人类灵长类动物和女性中使用雌激素替代疗法可以延缓动脉粥样硬化的进展，激素治疗可以降低双侧卵巢切除术后女性心血管疾病的发病率。这些研究结果支持在失去卵巢功能的年轻女性中使用激素治疗。
Premature menopause and bilateral oophorectomy in young women are associated with an increased incidence of cardiovascular disease, myocardial infarction and overall mortality. Observational studies suggest an interval of 5-10 years between loss of ovarian function and the increased risk of cardiovascular disease. This finding is consonant with a published autopsy study of women who had undergone bilateral oophorectomy. The progression of atherosclerosis is retarded with the use of estrogen replacement therapy in non-human primates and women.Hormone therapy reduced the incidence of cardiovascular disease in women following bilateral oophorectomy. These findings support the use of hormone therapy in young women who have lost ovarian function.