What is the function of hippocampal theta Rhythm? Linking behavioral data to phasic properties of field potential and unit recording data
What is the function of hippocampal theta Rhythm? Linking behavioral data to phasic properties of field potential and unit recording data
复制标题
DOI：
10.1002/hipo.20116
复制
发表时间：
2005-01-01
期刊：
影响因子：
3.5
通讯作者：
Hasselmo, ME
中科院分区：
文献类型：
--
作者：
Hasselmo, ME
大量关于海马theta节律的生理数据为评估theta节律对海马网络功能的作用的假设提供了机会。基于这些假设的计算模型有助于将行为数据与theta节律期间不同变量的生理测量联系起来。本文综述了theta节律在以下方面的研究成果：1)分离编码和检索的动态；2)增强序列的上下文依赖检索；3)缓冲内鼻皮层（EC）的新信息以进行情景编码；4)前额叶皮层和海马之间的定时相互作用以进行记忆引导的动作选择。模型显示了这些功能机制如何与海马体形成的生理数据相关，包括：(1)通过对CA1区和齿状回的脑电图数据的电流源密度分析测量的θ节奏期间突触电流的相位关系，(2)动作电位的时间，包括在线性轨道上运行时单个位置细胞的θ相进动，每天试验中θ波相进动的情境依赖性变化，以及空间交替（如“分裂细胞”）中海马神经元的情境依赖性放电特性，(3)内嗅皮质神经元持续活动的胆碱能调节，以及(4)前额皮质神经元相对于海马体θ波节律的相位时序。(c) 2005 Wiley-Liss, Inc。
The extensive physiological data on hippocampal theta rhythm provide an opportunity to evaluate hypotheses about the role of theta rhythm for hippocampal network function. Computational models based on these hypotheses help to link behavioral data with physiological measurements of different variables during theta rhythm. This paper reviews work on network models in which theta rhythm contributes to the following functions: (1) separating the dynamics of encoding and retrieval, (2) enhancing the context-de pendent retrieval of sequences, (3) buffering of novel information in entorhinal cortex (EC) for episodic encoding, and (4) timing interactions between prefrontal cortex and hippocampus for memory-guided action selection. Modeling shows how these functional mechanisms are related to physiological data from the hippocampal formation, including (1) the phase relationships of synaptic currents during theta rhythm measured by current source density analysis of electroencephalographic data from region CA1 and dentate gyrus, (2) the timing of action potentials, including the theta phase precession of single place cells during running on a linear track, the context-dependent changes in theta phase precession across trials on each day, and the context-dependent firing properties of hippocampal neurons in spatial alternation (e.g.,''splitter cell''), (3) the cholinergic regulation of sustained activity in entorhinal cortical neurons, and (4) the phasic timing of prefrontal cortical neurons relative to hippocampal theta rhythm. (c) 2005 Wiley-Liss, Inc.