SLEEP REGULATION IN RATS DURING EARLY DEVELOPMENT
SLEEP REGULATION IN RATS DURING EARLY DEVELOPMENT
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DOI：
10.1152/ajpregu.1990.258.3.r634
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发表时间：
1990-03-01
影响因子：
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通讯作者：
BORBELY, AA
中科院分区：
文献类型：
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作者：
ALFOLDI, P;TOBLER, I;BORBELY, AA
在自由活动的幼鼠中测定睡眠状态和脑电图（EEG）功率谱。 24 小时内的记录是从三个不同年龄的相同动物身上获得的。在 23 天的时候，在 12 小时的黑暗期中醒来就已经占主导地位。快速眼动睡眠 (REMS) 在 23 至 40 天之间下降。其24小时最大值出现在23日龄和29日龄时的黑暗期以及40日龄时的光照期。非REMS（NREMS）脑电图的慢波活动（SWA；0.75-4.0 Hz）显示出明显的与年龄相关的变化：12小时光照周期的下降趋势在23天时不存在，在29天时中等，在40天时显着。第 23 天时，SWA 随着超昼夜睡眠发作而逐渐下降，而第 24 天时，在 2 小时睡眠剥夺 (SD) 后，SWA 大幅增加。 30 日龄时，6 小时 SD 引起的变化要小得多。高频活动（10.25-25.0 Hz）的独特 24 小时模式存在于所有年龄段，并且可能代表昼夜节律过程的脑电图相关性。我们得出的结论是，调节 NREMS 强度的稳态机制在断奶后几天就已经发挥作用。
Sleep states and power spectra of the electroencephalogram (EEG) were determined in freely moving young rats. Recordings during 24 h were obtained from the same animals at three different ages. Already at the age of 23 days waking predominated in the 12-h dark period. Rapid-eye-movement sleep (REMS) declined between the age of 23 and 40 days. Its 24-h maximum was situated in the dark period at 23 and 29 days of age and in the light period at 40 days. Slow-wave activity (SWA; 0.75-4.0 Hz) of the non-REMS (NREMS) EEG showed marked age-related changes: a declining trend in the 12-h light period was absent at 23 days, moderate at 29 days, and prominent at 40 days. At 23 days, SWA progressively declined with ultradian sleep episodes and at 24 days was massively increased after 2-h sleep deprivation (SD). At the age of 30 days, 6-h SD induced much smaller changes. The distinct 24-h pattern of high-frequency activity (10.25-25.0 Hz) was present at all ages and may represent an EEG correlate of a circadian process. We conclude that homeostatic mechanisms regulating NREMS intensity are already operative a few days after weaning.