Expression of IL-6 in the ischemic penumbra
Expression of IL-6 in the ischemic penumbra
复制标题
DOI：
10.1097/00001756-200004070-00013
复制
发表时间：
2000-04-07
期刊：
影响因子：
1.7
通讯作者：
Nolden-Koch, M
中科院分区：
文献类型：
--
作者：
Block, F;Peters, M;Nolden-Koch, M
我们检测了短暂性（3 h）大脑中闭塞（MCA-O）后不同时间点缺血半暗带内IL-6的表达。这些动物分别在手术后1、3、7或14天被杀死。对冠状脑切片进行免疫组织化学处理，采用抗GFAP、OX 42、IL-6和nissl染色。半暗带内的胶质细胞在缺血后第1天开始激活，并持续到第14天。假手术对照组无IL-6表达。MCA-O后1天半暗区出现少量il -6阳性细胞。IL-6的表达在第3天增加，并持续到第14天。根据il -6阳性细胞的形状，它们似乎是小胶质细胞和神经元。目前的结果表明，IL-6在缺血半暗区持续表达。《神经病学报告》（11）：963-967 (C) 2000。
We examined the expression of IL-6 within the ischemic penumbra at various time points after transient (3 h) middle cerebral occlusion (MCA-O) in rats. The animals were killed at 1, 3, 7 or 14 days following operation. Coronal brain sections were processed for immunohistochemistry with antibodies against GFAP, OX 42, IL-6 and Nissl-staining. Glial activation within the penumbra started on day one after ischemia and persisted up to day 14. Expression of IL-6 was not present in sham-operated controls. One day after MCA-O there were several IL-6-positive cells in the penumbra. This expression of IL-6 increased on day 3 and remained elevated up to day 14. According to the shape of the IL-6-positive cells they seem to be microglia and neurons. The present results demonstrate a longlasting expression of IL-6 in the ischemic penumbra. NeuroReport 11:963-967 (C) 2000 Lippincott Williams & Wilkins.