Burden of ischemic stroke in Korea: analysis of disability-adjusted life years lost.
Burden of ischemic stroke in Korea: analysis of disability-adjusted life years lost.
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DOI：
10.3988/jcn.2011.7.2.77
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Lee BC
中科院分区：
文献类型：
--
作者：
Hong KS;Kim J;Cho YJ;Seo SY;Hwang SI;Kim SC;Kim JE;Kim A;Cho JY;Park HK;Bae HJ;Yang MH;Jang MS;Han MK;Lee J;Kang DW;Park JM;Koo J;Yu KH;Oh MS;Lee BC
残疾调整生命年（DALY），包括残疾和死亡率，已被广泛用于衡量地区和全球中风的负担。到目前为止，仅使用粗略的人群水平数据来估计人群中因卒中而损失的DALY;以前的研究没有纳入卒中登记的精确数据。本研究的目的是整合卒中登记数据和人群水平的发病率数据，以预测全国范围内缺血性卒中的DALY损失。根据两个大型缺血性卒中登记中心的数据，我们得出了以下年龄组中缺血性卒中导致的平均DALY损失：<45岁、45-54岁、55-64岁、65-74岁、75-84岁和≥85岁。全国范围内各年龄组缺血性卒中的发病率是从一项分析2004年韩国健康保险数据库的心脑血管监测研究中提取的。年龄组<45岁、45-54岁、55-64岁、65-74岁、75-84岁和≥85岁的缺血性卒中导致的平均DALY损失分别为5.07、4.63、4.35、3.88、2.88和1.73。通过将发病率乘以平均DALY损失，确定全国范围内的DALY损失分别为：<45岁为9，952，45-54岁为24，608，55-64岁为50，682，65-74岁为88，875，75-84岁为52，089，≥85岁为8，192。2004年，由于64，688例缺血性中风而导致的全国DALY损失预计为234，399例（男性121，482例，女性113，244例），每100，000人年的DALY损失为483例（男性500例，女性469例）。来自人群研究的发病率数据和来自卒中登记的DALY值可以整合，以提供全国范围内缺血性卒中负担的更精确预测。在韩国，由于缺血性中风，每年有超过230，000年的健康生命丧失，因此必须采取迅速行动。
Disability-adjusted life years (DALY), incorporating both disability and mortality, has been widely employed to measure regional and global burdens of stroke. Thus far, the DALY lost to stroke in a population has been estimated using only the crude population-level data; no previous study has incorporated refined data from stroke registries. The aim of this study was to integrate the stroke registry data and the population-level incidence data to project the nationwide DALY lost to ischemic stroke. From the data of two large ischemic stroke registries, we derived an average DALY lost due to ischemic stroke for each of the following age groups: <45, 45-54, 55-64, 65-74, 75-84, and ≥85 years. The nationwide ischemic stroke incidence for each age group was extracted from a cardiovascular and cerebrovascular surveillance study that analyzed the 2004 Korean Health Insurance database. The average DALY lost due to ischemic stroke for the age groups <45, 45-54, 55-64, 65-74, 75-84, and ≥85 years was 5.07, 4.63, 4.35, 3.88, 2.88, and 1.73, respectively. By multiplying the incidence and the average DALY lost, the nationwide DALY lost was determined to be 9,952 for those <45 years, 24,608 for 45-54 years, 50,682 for 55-64 years, 88,875 for 65-74 years, 52,089 for 75-84 years, and 8,192 for ≥85 years, respectively. The projected nationwide DALY lost due to 64,688 ischemic strokes in 2004 was 234,399 (121,482 for men and 113,244 for women), and the DALY lost per 100,000 person-years was 483 (500 for men and 469 for women). Incidence data from a population study and DALY values derived from stroke registries can be integrated to provide a more refined projection of the nationwide burden of ischemic stroke. In Korea, more than 230,000 years of healthy life are being lost annually due to ischemic stroke, and hence prompt action is imperative.
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