Aortic valve sclerosis and aortic atherosclerosis: Different manifestations of the same disease? Insights from a population-based study
Aortic valve sclerosis and aortic atherosclerosis: Different manifestations of the same disease? Insights from a population-based study
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DOI：
10.1016/s0735-1097(01)01422-x
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发表时间：
2001-09-01
影响因子：
24
通讯作者：
Tajik, AJ
中科院分区：
文献类型：
--
作者：
Agmon, Y;Khandheria, BK;Tajik, AJ
本研究的目的是探讨动脉粥样硬化危险因素、主动脉粥样硬化和主动脉瓣异常之间的关系。背景临床和实验研究表明，主动脉瓣硬化（AVS）是动脉粥样硬化过程的一种表现。（明尼苏达州）人群，进行了检查经胸和经食管超声心动图。确定是否存在AVS（瓣叶增厚）、经主动脉血流速度升高和主动脉瓣反流（AR）。动脉粥样硬化危险因素与主动脉粥样硬化的关系（经食管超声心动图成像）和主动脉瓣异常进行了检查。（比值比[OR]：1.07/kg/m2; 95%置信区间[CI]：1.02 - 1.12），抗高血压治疗（OR：1.93; CI：1.12 - 3.32）和血浆同型半胱氨酸水平（OR：1.89/2倍增加; CI：0.99 - 3.61）与AVS风险增加独立相关。年龄、体重指数和脉压（OR：1.21/10 mm Hg; CI：1.00 - 1.46）与经主动脉血流速度升高（上五分位数）相关，而只有年龄与AR独立相关。窦管交界处硬化（p = 0.001）和升主动脉粥样硬化（p = 0.03）是独立相关的AVS和升高transaortic velocities，respectively.CONCLUSIONS动脉粥样硬化的危险因素和近端主动脉粥样硬化是独立相关的主动脉瓣在一般人群中的异常。这些观察结果表明，AVS是一个动脉粥样硬化样过程涉及主动脉瓣。(C)2001年，美国心脏病学会。
OBJECTIVES The aim of this study was to examine the association between atherosclerosis risk factors, aortic atherosclerosis and aortic valve abnormalities in the general population.BACKGROUND Clinical and experimental studies suggest that aortic valve sclerosis (AVS) is a manifestation of the atherosclerotic process.METHODS Three hundred eighty-one subjects, a sample of the Olmsted County (Minnesota) population, were examined by transthoracic and transesophageal echocardiography. The presence of AVS (thickened valve leaflets), elevated transaortic flow velocities and aortic regurgitation (AR) was determined. The associations between atherosclerosis risk factors, aortic atherosclerosis (imaged by transesophageal echocardiography) and aortic valve abnormalities were examined.RESULTS Age, male gender, body mass index (odds ratio [OR]: 1.07 per kg/m(2); 95% confidence interval [CI]: 1.02 to 1.12), antihypertensive treatment (OR: 1.93; CI: 1.12 to 3.32) and plasma homocysteine levels (OR: 1.89 per twofold increase; CI: 0.99 to 3.61) were independently associated with an increased risk of AVS. Age, body mass index and pulse pressure (OR: 1.21 per 10 mm Hg; CI: 1.00 to 1.46) were associated with elevated (upper quintile) transaortic velocities, whereas only age was independently associated with AR. Sinotubular junction sclerosis (p = 0.001) and atherosclerosis of the ascending aorta (p = 0.03) were independently associated with AVS and elevated transaortic velocities, respectively.CONCLUSIONS Atherosclerosis risk factors and proximal aortic atherosclerosis are independently associated with aortic valve abnormalities in the general population. These observations suggest that AVS is an atherosclerosis-like process involving the aortic valve. (C) 2001 by the American College of Cardiology.