Chromosome abnormalities of leukemia cells in adult patients with T-cell leukemia.
Chromosome abnormalities of leukemia cells in adult patients with T-cell leukemia.
复制标题
成年 T 细胞白血病患者的白血病细胞染色体异常。
DOI：
10.1093/jnci/73.2.353
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
K. Kitajima
中科院分区：
文献类型：
--
作者：
K. Miyamoto;N. Tomita;A. Ishii;H. Nonaka;T. Kondo;T. Tanaka;K. Kitajima
对 30 名成人 T 细胞白血病患者的染色体进行了分析。所有接受检查的患者均发现染色体异常。异常细胞染色体数目众态为亚二倍体2例，二倍体14例，超二倍体9例。其余5例患者染色体数目双峰（二倍体和超二倍体模式）。尽管所有患者都表现出不同数量或结构的染色体异常，但他们也有共同的染色体异常。 30 例患者中，20 例发现 1 号染色体畸变，20 例发现 3 号染色体畸变，17 例发现 6 号染色体或 6q-三体性畸变，16 例发现 10 号染色体畸变，9 例发现 14 号染色体长臂畸变，7 例发现 18 三体性。临床症状的差异与临床症状的差异没有特殊关系。染色体异常。
Chromosomes of 30 patients with adult T-cell leukemia were analyzed. Chromosome abnormalities were found in all the patients examined. The modal chromosome number of abnormal cells was hypodiploid in 2 patients, diploid in 14, and hyperdiploid in 9. The remaining 5 patients had bimodal chromosome numbers (diploid and hyperdiploid modes). Although all the patients showed various numerical or structural chromosome abnormalities, they also had common chromosome abnormalities. Aberrations of chromosome 1 were noted in 20 of the 30 patients, aberrations of chromosome 3 were seen in 20, trisomy 6 or 6q- was found in 17, aberrations of chromosome 10 were noted in 16, aberrations of the long arm of chromosome 14 were seen in 9, and trisomy 18 was seen in 7. There was no particular relationship between the difference in clinical symptoms and disparity in chromosome abnormalities.