Validity of mother's history regarding antimalarial drug use in Malawian children under five years old
Validity of mother's history regarding antimalarial drug use in Malawian children under five years old
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DOI：
10.1016/s0035-9203(96)90482-4
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发表时间：
1996-01-01
影响因子：
2.2
通讯作者：
Chitsulo, L
中科院分区：
文献类型：
--
作者：
Nwanyanwu, OC;Redd, SC;Chitsulo, L
从父母和照顾者那里获得的病史是治疗儿童疟疾的卫生工作者的重要信息来源，通常也是唯一的信息来源，但其有效性尚未得到很好的评价。在马拉维的2家医院，我们从973名患病儿童的母亲那里获得了疟疾治疗史，这些儿童报告说发烧是疾病的一部分。从973名儿童中的755名（78%）收集了尿液样本。在755人中，457人（61%）据报接受了某种治疗。在据报告接受治疗的人中，据说有79人（17%）接受了氯喹，23人（5%）接受了含磺胺的药物;然而，在对尿液样本进行抗疟药物检测时，在182个样本（40%）中发现了氯喹，在148个样本（32%）中发现了磺胺。在从291名据报告未接受治疗的儿童（7名儿童未报告）收集的尿液样本中，56名（19%）检测到氯喹，44名（15%）检测到磺胺。尽管没有统计学意义，但如果孩子小于12个月或患病超过3天，母亲经常报告孩子没有接受抗疟药物。母亲们关于在家治疗儿童发热的信息非常不准确。疟疾治疗史，无论是在卫生机构收集的，还是在知识、态度和实践调查中收集的，都必须谨慎解释。
History obtained from parents and carers is an important, and often the only, source of information for health workers treating children for malaria, but its validity has not been well evaluated, At 2 hospitals in Malawi, we obtained malaria treatment histories from mothers of 973 ill children reported to have had fever as part of the illness. Urine samples were collected from 755 of the 973 children (78%). Of the 755, 457 (61%) were reported to have received some kind of treatment. Among those who reportedly received treatment, 79 (17%) were said to have received chloroquine and 23 (5%) a sulphonamide-containing medicine; however, when urine specimens were tested for antimalarial drugs, chloroquine was found in 182 specimens (40%) and a sulphonamide in 148 (32%). Among urine specimens collected from 291 children who were reported to have received no treatment (no report was recorded for 7 children), chloroquine was detected in 56 (19%) and a sulphonamide in 44 (15%). Although not statistically significant, mothers often reported a child as not having received an antimalarial drug if the child was younger than 12 months or had been sick for more than 3 d. The mothers' information regarding home treatment of fever in children was highly inaccurate. Malaria treatment histories, whether collected at health facilities or in surveys of knowledge, attitudes, and practices, must be interpreted with caution.