Body Composition as Determinant of Thrombin Generation in Plasma The Hoorn Study
Body Composition as Determinant of Thrombin Generation in Plasma The Hoorn Study
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DOI：
10.1161/atvbaha.110.211946
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发表时间：
2010-12-01
影响因子：
8.7
通讯作者：
Stehouwer, Coen D. A.
中科院分区：
文献类型：
--
作者：
Beijers, Hanneke J. B. H.;Ferreira, Isabel;Stehouwer, Coen D. A.
肥胖与心血管疾病和静脉血栓栓塞之间的联系可能，至少部分地，可以用高凝状态来解释。体脂肪量及其分布对高凝状态的影响程度尚不清楚。在这项研究中，我们调查了身体成分和凝血酶生成之间的关联，并评估了潜在的介导作用的低度inflammation.Methods和结果，我们研究了586个人从Hoorn研究（平均年龄，69.7 +/- 6.5岁，298名妇女），其中身体成分进行了评估全身双能吸收测定法。使用校准的自动血栓图测量凝血酶生成。多元回归分析显示，女性体内总脂肪和凝血酶生成之间存在正相关，而男性则没有。此外，详细的区域身体成分分析表明，中心，而不是周边的脂肪量与凝血酶生成量更大，有一个趋势，与周边瘦体重呈负相关。报告的积极协会被部分衰减的低度炎症，然而。结论体脂肪量，特别是中央模式的脂肪分布，与较高水平的凝血酶生成老年妇女，但不是在男性。这种关联可能部分由肥胖相关的低度炎症解释，但这一假设需要在机制/前瞻性研究中进一步研究。（Arterioscler Thromb Vasc Biol.2010;30：2639-2647.）
Objective-The association between obesity and cardiovascular disease and venous thromboembolism might, at least partially, be explained by a hypercoagulable state. The extent to which body fat mass and its distribution contribute to a hypercoagulable state is unknown. In this study, we investigated the association between body composition and thrombin generation and evaluated the potential mediating role of low-grade inflammation.Methods and Results-We studied 586 individuals from the Hoorn Study (mean age, 69.7 +/- 6.5 years, 298 women) in whom body composition was assessed by whole body dual-energy absorptiometry. Thrombin generation was measured using the Calibrated Automated Thrombogram. Multiple regression analyses showed a positive association between total body fat and thrombin generation in women but not in men. In addition, detailed analyses of regional body composition showed that central but not peripheral fat mass was associated with greater thrombin generation and that there was a trend toward an inverse association with peripheral lean mass. The reported positive associations were partially attenuated by low-grade inflammation, however.Conclusion-Body fat mass, in particular a central pattern of fat distribution, is associated with higher levels of thrombin generation in elderly women but not in men. This association may partially be explained by adiposity-related low-grade inflammation, but this hypothesis needs to be further investigated in mechanistic/prospective studies. (Arterioscler Thromb Vasc Biol. 2010;30:2639-2647.)