Effect of HIV on thymic function before and after antiretroviral therapy in children
Effect of HIV on thymic function before and after antiretroviral therapy in children
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DOI：
10.1086/315398
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发表时间：
2000-04-01
影响因子：
6.4
通讯作者：
Luzuriaga, K
中科院分区：
文献类型：
--
作者：
Douek, DC;Koup, RA;Luzuriaga, K
研究了胸腺在接受抗逆转录病毒治疗的人类免疫缺陷病毒（HIV）感染儿童T细胞重建中的作用。9例在围产期获得HIV的儿科患者接受了抗逆转录病毒药物的多药组合治疗。检测血浆病毒载量、CD 4+和CD 8 + T细胞亚群，并通过定量外周血T细胞受体重排切除环测定胸腺功能。病毒载量>400 RNA拷贝/ mt血浆的患者被归类为病毒学无应答者。所有受试者的Thr功能最初均降低。抗逆转录病毒治疗后，所有受试者外周血CD 4（+）T细胞均升高。5例病毒学应答者中有4例恢复了胸腺功能，但4例病毒学无应答者中仅1例恢复了胸腺功能。这表明HIV对儿童HIV感染者的胸腺功能有不良影响。有效的抗逆转录病毒治疗恢复胸腺功能，但受病毒抑制程度的影响。
Studies were undertaken to investigate the role of the thymus in T cell reconstitution in human immunodeficiency virus (HIV)-infected children treated with antiretroviral therapy. Nine pediatric patients who acquired HIV perinatally were treated with multidrug combinations of antiretroviral agents. Plasma virus load and CD4(+) and CD8(+) T cell subsets were measured, and thymus function was measured by quantifying T cell receptor rearrangement excision circles in peripheral blood. Patients with virus loads remaining >400 RNA copies/ mt plasma were classified as virologic nonresponders, Thymus function was initially decreased in all subjects. After antiretrovirus therapy, peripheral CD4(+) T cells increased in all subjects. Thymus function was restored in 4 of 5 virologic responders but in only 1 of 4 virologic nonresponders. This suggests that HIV has an adverse effect upon thymic function in pediatric HIV infection. Potent antiretroviral therapy restores thymic function but is affected by the degree to which virus suppression is achieved.