Microsomal triglyceride transfer protein (MTP)-493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients
Microsomal triglyceride transfer protein (MTP)-493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients
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DOI：
10.1111/j.1365-2893.2008.00994.x
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发表时间：
2008-10-01
影响因子：
2.5
通讯作者：
Adinolfi, L. E.
中科院分区：
文献类型：
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作者：
Zampino, R.;Ingrosso, D.;Adinolfi, L. E.
(A)微粒体甘油三酯转移蛋白（MTP）是脂蛋白组装/分泌的关键酶，其活性降低与HCV脂肪变性有关。宿主遗传背景可能影响脂肪变性的发生。本研究的目的是探讨丙型肝炎患者MTP-493 G/T基因多态性与脂肪肝积累和肝纤维化进展的关系。共对102例经肝活检证实的慢性丙型肝炎初治患者进行了MTP-493 G/T基因多态性、HCV RNA、HCV基因型、HOMA-IR、血清脂联素、TNF-α和血脂水平的评估。携带MTP基因多态性T等位基因的HCV基因3型感染者比携带GG基因型的患者脂肪变性程度更高（分别为3.45 ± 0.37和1.30 ± 0.45; P < 0.001）。MTP“T”等位基因携带者血清HCVRNA水平显著高于对照组（P < 0.01），肝纤维化程度显著高于对照组（P < 0.001）。与MTP基因型无关，HCV基因型3的患者胆固醇、ApoB、HDL和LDL水平较低。在HCV基因型非3型感染者中，没有参数与MTP基因多态性相关。结论：MTP-493 G/T基因多态性T等位基因的存在使HCV基因3型感染患者发生更高程度的脂肪肝蓄积。
(A) A reduced activity of microsomal triglyceride transfer protein (MTP), a key enzyme of assembly/secretion of lipoproteins, is related to HCV steatosis. Host genetic background may influence development of steatosis. The aim of the study was to investigate the association between MTP-493 G/T gene polymorphism, fat liver accumulation and fibrosis progression in HCV infected patients. A total of 102 naive patients with liver biopsy proven chronic hepatitis C were evaluated for MTP-493 G/T gene polymorphism, HCV RNA, HCV genotype, HOMA-IR, serum adiponectin, TNF-alpha and serum lipid levels. HCV genotype 3 infected patients carrying the T allele of the MTP gene polymorphism showed higher degree of steatosis than those carrying GG genotype (3.45 +/- 0.37 vs 1.30 +/- 0.45, respectively; P < 0.001). MTP 'T' allele carriers also had higher HCV RNA serum levels (P < 0.01) and hepatic fibrosis (P < 0.001). Irrespective of MTP genotype, patients with HCV genotype 3 had lower levels of cholesterol, ApoB, HDL and LDL. In HCV genotype non-3 infected patients no parameters were associated with MTP gene polymorphism. In conclusion the presence of T allele of MTP-493G/T gene polymorphism predisposes patients infested with HCV genotype 3 to develop higher degree of fatty liver accumulation.