NORADRENERGIC AND DOPAMINERGIC INTERACTIONS IN ESCAPE BEHAVIOR - ANALYSIS OF UNCONTROLLABLE STRESS EFFECTS
NORADRENERGIC AND DOPAMINERGIC INTERACTIONS IN ESCAPE BEHAVIOR - ANALYSIS OF UNCONTROLLABLE STRESS EFFECTS
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DOI：
10.1007/bf00427107
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发表时间：
1981-01-01
影响因子：
3.4
通讯作者：
SKLAR, LS
中科院分区：
文献类型：
--
作者：
ANISMAN, H;RITCH, M;SKLAR, LS
The effects of norepinephrine receptor blockade on the deficits of escape behavior induced by haloperidol and by inescapable shock were evaluated in mice. Phenoxybenzamine, the .alpha.-norepinephrine receptor blocker, enhanced escape behavior and eliminated the disruptive effects of both inescapable shock and haloperidol. The .beta.-norepinephrine receptor antagonist, propranolol, was without effect on behavior under any of these conditions, while the dopamine-.beta.-hydroxylase inhibitor, FLA-63 [bis(4-methyl-l-homopiperazinylthiocarbonyl)disulfide], disrupted performance. Like phenoxybenzamine, the norepinephrine receptor stimulant, clonidine, eliminated the behavioral disruption produced by haloperidol. These somewhat paradoxical findings were discussed in terms of the contribution of dopamine-norepinephrine interactions in determining behavioral change in aversive paradigms.
