SAFETY OF AZATHIOPRINE IN PREGNANCY IN INFLAMMATORY BOWEL-DISEASE
SAFETY OF AZATHIOPRINE IN PREGNANCY IN INFLAMMATORY BOWEL-DISEASE
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DOI：
10.1016/0016-5085(90)91027-4
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发表时间：
1990-08-01
期刊：
影响因子：
29.4
通讯作者：
CLARK, ML
中科院分区：
文献类型：
--
作者：
ALSTEAD, EM;RITCHIE, JK;CLARK, ML
尽管有报道称硫唑嘌呤在妊娠期对肾移植受者和系统性红斑狼疮患者是安全的，但对于炎症性肠病是否应该在妊娠期继续使用，意见不一。对14名服用硫唑嘌呤治疗炎症性肠病的妇女的16例妊娠结局进行了回顾性分析。有一个妊娠的感染性并发症(乙肝病毒感染)，但孩子们没有先天性异常或随后的健康问题。这项初步研究表明，硫唑嘌呤在炎症性肠病患者的怀孕期间是安全的，服用该药物时怀孕的人不是强制终止妊娠的。
Although azathioprine has been reported to be safe during pregnancy in renal transplant recipients and patients with systemic lupus erythematosus, opinions vary whether it should be continued in pregnancy in inflammatory bowel disease. A retrospective analysis of the outcome of 16 pregnancies in 14 women receiving azathioprine for inflammatory bowel disease was performed. There was one infective complication of pregnancy (hepatitis B virus infection), but there were no congenital abnormalities or subsequent health problems in the children. This preliminary study suggests that azathioprine is safe in pregnancy in inflammatory bowel disease patients and that termination of pregnancy is not mandatory for those who conceive while taking the drug.