Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome
Long-term survival and parenteral nutrition dependence in adult patients with the short bowel syndrome
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DOI：
10.1016/s0016-5085(99)70388-4
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发表时间：
1999-11-01
期刊：
影响因子：
29.4
通讯作者：
Matuchansky, C
中科院分区：
文献类型：
--
作者：
Messing, B;Crenn, P;Matuchansky, C
背景和目的：短肠综合征（SBS）可能与暂时性或永久性肠衰竭有关，目前通过肠外营养（PN）治疗。考虑到小肠残余长度和吻合消化回路的类型，成人 SBS 患者的生存率和 PN 依赖性尚不清楚。本研究的目的是评估此类预后因素。方法：1980 年至 1992 年间，2 个家庭 PN 中心连续招募了 124 名患有非恶性 SBS 的成人。使用 Cox 模型分析它们的生存概率和 PN 依赖性概率，并使用线性判别分析分析它们的 PN 依赖性。数据于 1996 年 4 月更新。结果：2 年和 5 年生存率和 PN 依赖性概率分别为 86% 和 49% 以及 75% 和 45%。在多变量分析中，生存率与末端肠造口术、小肠长度呈负相关。
Background & Aims: The short bowel syndrome (SBS) may be associated with either transient or permanent intestinal failure, presently treated by parenteral nutrition (PN). Survival and PN-dependence probabilities, taking into account both small bowel remnant length and the type of the digestive circuit of anastomosis, are not known in adult SBS patients. The aim of this study was to assess such prognostic factors. Methods: A total of 124 consecutive adults with nonmalignant SBS were enrolled from 1980 to 1992 at 2 home PN centers. They were analyzed for survival and PN-dependence probabilities using the Cox model and for PN dependence using linear discriminant analysis. Data were updated in April 1996. Results: Survival and PN-dependence probabilities were 86% and 49% and 75% and 45% at 2 and 5 years, respectively. In multivariate analysis, survival was related negatively to end-enterostomy, to small bowel length of