The antibody response to 27-, 17-, and 15-kDa Cryptosporidium antigens following experimental infection in humans.
The antibody response to 27-, 17-, and 15-kDa Cryptosporidium antigens following experimental infection in humans.
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人类实验性感染后抗体对 27、17 和 15 kDa 隐孢子虫抗原的反应。
DOI：
10.1086/515377
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Lammie,PJ
中科院分区：
文献类型：
--
作者：
Moss,DM;Chappell,CL;Okhuysen,PC;DuPont,HL;Arrowood,MJ;Hightower,AW;Lammie,PJ
以前的研究表明，感染隐孢子虫的人对27-、17-和15-kDaC产生抗体反应。细小抗原对感染隐孢子虫的志愿者的研究提供了一个机会来评价抗体对这些抗原的反应性和感染结果之间的关系。通过免疫印迹监测，特异性抗体反应性的增加在出现隐孢子虫病体征和症状的志愿者（n= 11）中比无症状感染者（n= 7;P= 0.05）或卵囊阴性志愿者（n= 11;P= 0.02）更普遍。预先存在27 kDa抗原IgG抗体的志愿者比没有这种抗体的志愿者排出更少的卵囊（P= 0.003）。在第0天，无症状感染者对17 kDa抗原的IgG反应性和对27 kDa抗原的IgM反应性高于出现症状者（分别为P= 0.03和P = 0.04）。这些结果表明，特征性抗体反应发展以下C。因此，我们认为，人感染细小病毒，而预先存在抗体的人可能不太可能发展成疾病。
Previous studies have suggested that persons infected withCryptosporidium parvumdevelop antibody responses to 27-, 17-, and 15-kDaC. parvumantigens. Studies of volunteers infected withCryptosporidiumspecies provided an opportunity to evaluate the relationship between antibody reactivity to these antigens and infection outcome. As monitored by immunoblot, increases in specific antibody reactivity were more prevalent among volunteers who developed signs and symptoms of cryptosporidiosis (n= 11) than among asymptomatic infected (n= 7;P= .05) or oocyst-negative volunteers (n= 11;P= .02). Volunteers with preexisting IgG antibody to the 27-kDa antigen excreted fewer oocysts than volunteers without this antibody (P= .003). IgG reactivity to the 17-kDa antigens and IgM reactivity to the 27-kDa antigens were higher at day 0 for asymptomatic infected persons than for those who developed symptoms (P= .03 andP= .04, respectively). These results suggest that characteristic antibody responses develop followingC. parvuminfection and that persons with preexisting antibodies may be less likely to develop illness.