Automated Segmentation of the Choroid from Clinical SD-OCT
Automated Segmentation of the Choroid from Clinical SD-OCT
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DOI：
10.1167/iovs.12-10311
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发表时间：
2012-11-01
影响因子：
4.4
通讯作者：
Abramoff, Michael D.
中科院分区：
文献类型：
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作者：
Zhang, Li;Lee, Kyungmoo;Abramoff, Michael D.
目的.我们开发并评估了一种全自动三维（3D）方法，用于脉络膜血管的分割，脉络膜血管厚度和脉络膜毛细血管等效黄斑厚度的量化，并使用标准临床可用的光谱域光学相干断层扫描（SD-OCT）评估正常受试者的重复变异性。共24名正常受试者进行了两次成像，使用临床上可用的，3D SD-OCT。一种新的，全自动的3D方法被用来分割和可视化脉络膜血管在黄斑扫描。局部脉络膜血管和脉络膜毛细血管等效厚度进行了测定。使用重叠率、Dice系数和脉络膜血管和脉络膜毛细血管等效厚度的均方根变异系数（CV）分析重复成像的再现性。对于SD-OCT描绘的636 mm（2）黄斑中心区域，正常受试者的平均脉络膜血管厚度为172.1 μ m（95%置信区间[CI] 163.7-180.5 μ m），平均脉络膜毛细血管等效厚度为23.1 μ m（95% CI 20.0-26.2 μ m）。重叠率为0.79 ± 0.07和0.75 ± 0.06，Dice系数为0.78 ± 0.08，脉络膜血管厚度的CV为8.0%（95%CI 6.3%-9.4%），脉络膜毛细血管等效厚度的CV为27.9%（95%CI 21.0%-33.3%）。脉络膜血管和脉络膜毛细血管等效厚度的全自动3D分割和定量分析在重复扫描中表现出良好的再现性（CV 8.0%）和脉络膜毛细血管等效厚度的良好再现性（CV 27.9%）。我们的方法有可能改善脉络膜受影响的眼部疾病患者的诊断和管理。（Invest Ophthalmol维斯科学。2012; 53：7510-7519）DOI：10.1167/iovs.12-10311
PURPOSE. We developed and evaluated a fully automated 3-dimensional (3D) method for segmentation of the choroidal vessels, and quantification of choroidal vasculature thickness and choriocapillaris-equivalent thickness of the macula, and evaluated repeat variability in normal subjects using standard clinically available spectral domain optical coherence tomography (SD-OCT).METHODS. A total of 24 normal subjects was imaged twice, using clinically available, 3D SD-OCT. A novel, fully-automated 3D method was used to segment and visualize the choroidal vasculature in macular scans. Local choroidal vasculature and choriocapillaris-equivalent thicknesses were determined. Reproducibility on repeat imaging was analyzed using overlapping rates, Dice coefficient, and root mean square coefficient of variation (CV) of choroidal vasculature and choriocapillaris-equivalent thicknesses.RESULTS. For the 636 mm(2) macula-centered region as depicted by the SD-OCT, average choroidal vasculature thickness in normal subjects was 172.1 mu m (95% confidence interval [CI] 163.7-180.5 mu m) and average choriocapillaris-equivalent thickness was 23.1 mu m (95% CI 20.0-26.2 mu m). Overlapping rates were 0.79 +/- 0.07 and 0.75 +/- 0.06, Dice coefficient was 0.78 +/- 0.08, CV of choroidal vasculature thickness was 8.0% (95% CI 6.3%-9.4%), and of choriocapillaris-equivalent thickness was 27.9% (95% CI 21.0%-33.3%).CONCLUSIONS. Fully automated 3D segmentation and quantitative analysis of the choroidal vasculature and choriocapillaris-equivalent thickness demonstrated excellent reproducibility in repeat scans (CV 8.0%) and good reproducibility of choriocapillaris-equivalent thickness (CV 27.9%). Our method has the potential to improve the diagnosis and management of patients with eye diseases in which the choroid is affected. (Invest Ophthalmol Vis Sci. 2012; 53: 7510-7519) DOI:10.1167/iovs.12-10311