Acute exercise and gender alter cardiac autonomic tonus differently in hypertensive and normotensive rats
Acute exercise and gender alter cardiac autonomic tonus differently in hypertensive and normotensive rats
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DOI：
10.1152/ajpregu.1998.274.2.r510
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发表时间：
1998-02-01
影响因子：
2.8
通讯作者：
DiCarlo, SE
中科院分区：
文献类型：
--
作者：
Chandler, MP;DiCarlo, SE
测定自发性高血压大鼠（SHR，8男8女）和正常血压大鼠（WKY，8男12女）运动前后的动脉压（AP）、心率（HR）、心交感神经张力（ST）和副交感神经张力（PT）。运动前，高血压大鼠（不分性别）ST增加（+15次/min），静息心率增加（+12次/min），PT降低（-11次/min）。同样。雌性大鼠（不考虑品系）也具有ST增加（+15次/分钟）、静息HR增加（+39次/分钟）和PT降低（-14次/分钟）。高血压大鼠在运动后AP（-17 +/-3 mmHg）、ST（-26次/分）、PT（-7次/分）和HR（-14次/分）显著降低。相反，正常血压大鼠的AP没有降低，运动后雌性正常血压大鼠的ST（+18次/分）和HR（+42次/分）增加。然而，血压正常的雄性大鼠运动后ST（-14次/分）和HR（-19次/分）降低。总之，高血压大鼠与血压正常大鼠相比，AP、ST和静息HR较高，而PT较低。此外，雌性大鼠的静息HR、固有HR和ST均高于雄性大鼠，PT低于雄性大鼠。这些数据表明，性别和静息AP水平影响心脏自主调节。
Arterial pressure (AP), heart rate (HR), cardiac sympathetic tonus (ST), and parasympathetic tonus (PT) were determined in spontaneously hypertensive rats (SHR, 8 male and 8 female) and Wistar-Kyoto normotensive rats (WKY, 8 male and 12 female) before and after exercise. Before exercise, hypertensive rat (regardless of gender) had an increased ST (+15 beats/min), increased resting HR (+12 beats/min), and decreased PT (-11 beats/min). Similarly. female rats (regardless of strain) also had an increased ST (+15 beats/min), increased resting HR (+39 beats/min), and decreased PT (-14 beats/min). Hypertensive rats had a significant reduction in AP (-17 +/- 3 mmHg), ST (-26 beats/min), PT (-7 beats/min), and HR (-14 beats/min) after exercise. In contrast, AP was not reduced in normotensive rats and ST (+18 beats/min) and HR (+42 beats/min) were increased in female normotensive rats after exercise. However, male normotensive rats had a postexercise reduction in ST (-14 beats/min) and HR (-19 beats/min). In summary, AP, ST, and resting HR were higher whereas PT was lower in hypertensive vs. normotensive rats. Furthermore, females had a higher resting HR, intrinsic HR, and ST and lower PT than male rats. These data demonstrate that gender and the resting level of AP influence cardiac autonomic regulation.