Atopic myelitis: first case report outside Japan?
Atopic myelitis: first case report outside Japan?
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特应性脊髓炎：日本境外首例病例报告？
DOI：
10.1111/j.1398-9995.2004.00689.x
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发表时间：
2005
期刊：
影响因子：
12.4
通讯作者：
L. Antonicelli
中科院分区：
文献类型：
--
作者：
A. Zoli;M. Mariano;A. Fusari;F. Bonifazi;L. Antonicelli
在96例CSS患者的随访中，VTED发作（4）。有几个因素可以解释CSS和VTED之间的关联。首先，VTED可能仅仅是经典血栓栓塞危险因素如心力衰竭、制动或住院治疗的结果，正如我们的第一和第二例病例所证明的那样。其次，炎性疾病可能易导致血管血栓形成。例如，已经证明，患有炎症性肠病的患者发生急性VTED的风险增加了三倍（5）。更具体地说，嗜酸性粒细胞炎症可能是血栓形成事件的风险因素。对15例嗜酸性粒细胞增多综合征患者进行随访，描述了10例血栓栓塞并发症，包括2例VTED（6）。这种关联的一个可能的解释可能是嗜酸性粒细胞阳离子蛋白在体外与Hageman因子（XII）结合并激活凝血内源性途径的能力。总之，我们描述了10例CSS患者队列中的三次严重VTED发作。目前尚不清楚VTED是否是特定血管病变的结果或仅仅是经典VTED危险因素组合的结果。
episode of VTED in their follow up of 96 patients with CSS (4). Several factors may explain the association between CSS and VTED. First, VTED may be the mere consequence of classical thromboembolic risk factors such as heart failure, immobilization or hospitalization, as evidenced in our first and second cases. Secondly, inflammatory diseases may predispose to vascular thrombosis. For instance, it has been demonstrated that patients displaying inflammatory bowel disease have a threefold increased risk of developing acute VTED (5). More specifically, eosinophilic inflammation may be a risk factor for thrombotic events. Follow up of 15 patients with hypereosinophilic syndrome led to the description of 10 thromboembolic complications including two VTED (6). A possible explanation of this association could be the ability of eosinophil cationic protein to bind, in vitro, to Hageman factor (XII) and activate the intrinsic pathway of coagulation. In conclusion, we describe three episodes of severe VTED in a cohort of 10 CSS patients. It remains unclear whether VTED was the consequence of specific vascular lesions or the mere result of a combination of classical VTED risk factors.