Reproductive aging and its consequences for general health
Reproductive aging and its consequences for general health
复制标题
DOI：
10.1111/j.1749-6632.2010.05521.x
复制
发表时间：
2010-01-01
期刊：
影响因子：
--
通讯作者：
Santoro, Nanette
中科院分区：
文献类型：
--
作者：
Traub, Michael L.;Santoro, Nanette
生殖老化与内分泌变化相一致，这些内分泌变化在本质上不仅仅是生殖性的，并在高促性腺激素性功能减退和闭经中达到高潮。无论临床表现如何，这些变化在生化上都是可识别的。下丘脑-垂体-卵巢轴的变化与其他激素轴的变化相关，特别是肾上腺雄激素和促生长激素轴。大量的文献表明，生殖老化与生长激素轴的下降有关。生殖老化和肾上腺雄激素轴变化之间的相互作用更为复杂，在生殖年龄早期，肾上腺轴与年龄相关的下降使其更加复杂。这些变化可能在整体健康维护中发挥重要作用。试图改善激素下降与外源性激素治疗产生了混合的结果。最后，特定年龄的时间以及生殖老化发生的变化的速度似乎对代谢，心血管风险，认知，骨密度甚至死亡率都有重要影响。
Reproductive aging coincides with endocrine changes that are not solely reproductive in nature and culminates in hypergonadotropic hypogonadism and amenorrhea. These changes are identifiable biochemically regardless of clinical manifestations. Changes in the hypothalamic pituitary ovarian axis are associated with changes in other hormonal axes, specifically the adrenal androgen and the somatotropic axis. A large body of literature indicates that reproductive aging is associated with a decline in the somatotropic axis. The interactions between reproductive aging and changes in the adrenal androgen axis are more complex and complicated by age-related declines in the adrenal axis early in the reproductive years. These changes may play an important role in overall health maintenance. Attempts to ameliorate hormonal declines with exogenous hormonal therapy have produced mixed results. Finally, the age-specific timing as well as the rapidity of the changes that occur with reproductive aging seems to have important consequences on metabolism, cardiovascular risk, cognition, bone density, and even mortality.