HEMOGLOBIN CARBAMYLATION IN UREMIA
HEMOGLOBIN CARBAMYLATION IN UREMIA
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DOI：
10.1056/nejm198104023041406
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发表时间：
1981-01-01
影响因子：
158.5
通讯作者：
GABBAY, KH
中科院分区：
文献类型：
--
作者：
FLUCKIGER, R;HARMON, W;GABBAY, KH
红细胞溶血产物的色谱法可从主要血红蛋白A（HbA）组分中分离出四种次要血红蛋白组分。这些次要组分-HbA 1a 1、HbA 1a 2、HbAlb和HbA 1c-统称为HbA 1组分，约占正常受试者总血红蛋白的7%，主要由HbA的翻译后非酶糖基化产生。1HbAlc是最丰富的糖基化血红蛋白，葡萄糖通过稳定的酮胺键连接到β链的N末端氨基; HbA 1cis含量增加. . . . . .
CHROMATOGRAPHY of hemolysates of red cells resolves four minor hemoglobin components from the main hemoglobin A (HbA) fraction. These minor components — HbA1a1, HbA1a2, HbAlb, and HbA1c— collectively referred to as the HbA1fraction, make up approximately 7 per cent of total hemoglobin in normal subjects and result mainly from the post-translational, nonenzymatic glycosylation of HbA.1In HbAlc, the most abundant of the glycosylated hemoglobins, glucose is attached to the N-terminal amino group of the β chains by a stable ketoamine linkage; HbA1cis present in increased amounts . . .