Statin use and incident dementia: A nationwide cohort study of Taiwan
Statin use and incident dementia: A nationwide cohort study of Taiwan
复制标题
DOI：
10.1016/j.ijcard.2014.03.018
复制
发表时间：
2014-05-01
影响因子：
3.5
通讯作者：
Huang, Nicole
中科院分区：
文献类型：
--
作者：
Chou, Chian-Ying;Chou, Yueh-Ching;Huang, Nicole
背景：他汀类药物广泛应用于临床治疗。然而，一个美国。S.美国食品和药物管理局发布的健康警报引起了人们对他汀类药物相关混乱和老年人记忆丧失的不良影响的关注。有必要阐明他汀类药物的使用与痴呆发病风险之间的关系以及是否存在类效应。方法：在这项基于人群的回顾性队列研究中，从台湾全民健康保险研究数据库的一个子集中选择了33，398例年龄≥ 60岁的患者，并随访了2000年至2010年期间任何类型痴呆的发生情况。结果：与非他汀类药物使用者相比，他汀类药物使用者发生痴呆的风险显著降低（风险比[HR]，0.78; 95%CI，0.72-0.85，p < 0.001）。他汀类药物的效力和累积使用时间与痴呆风险的降低相关。按性别分层后，女性他汀类药物使用者痴呆发生的风险（HR，0.76; 95%CI，0.68-0.85，p < 0.001）低于男性他汀类药物使用者（HR，0.86; 95%CI，0.75-0.98，p = 0.024）。更高的效力和更长的累积持续时间的他汀类药物的使用，需要减少男性患者比女性patients.Conclusion：他汀类药物的使用与痴呆症的风险显着降低在台湾的老年患者。他汀类药物的效力和累积持续时间起着关键作用。(c)2014爱思唯尔爱尔兰有限公司版权所有。
Background: Statins are widely used in clinical treatment. However, an U. S. Food and Drug Administration issued health alert has raised concerns for the adverse effects of statin-associated confusion and memory loss in the elderly people. It is necessary to clarify the relationship between statin use and risk of incident dementia as well as whether class effects exist.Methods: In this population-based retrospective cohort study, total 33,398 patients aged >= 60 years were selected from a subset of the Taiwan National Health Insurance Research Databases and followed up for tracking the occurrence of any type of dementia from 2000 to 2010. The Cox proportional hazards models were used.Results: Compared to nonusers, statin users had a significantly lower risk of incident dementia (hazard ratio [HR], 0.78; 95% CI, 0.72-0.85, p < 0.001). The potency and the cumulative duration of statin utilized were associated with the reducing risk of dementia. After stratifying by gender, the risk of incident dementia was lower in female statin users (HR, 0.76; 95% CI, 0.68-0.85, p < 0.001) than in male statin users (HR, 0.86; 95% CI, 0.75-0.98, p = 0.024). Higher potency and longer cumulative duration of statin use were required for reducing the risk of incident dementia in male patients than in female patients.Conclusion: Statin use was associated with a significantly lower risk of dementia in the elderly patients in Taiwan. The potency and the cumulative duration of statin utilized played critical roles. (c) 2014 Elsevier Ireland Ltd. All rights reserved.