The 4q25, 1q21, and 16q22 polymorphisms and recurrence of atrial fibrillation after pulmonary vein isolation.
The 4q25, 1q21, and 16q22 polymorphisms and recurrence of atrial fibrillation after pulmonary vein isolation.
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DOI：
10.5114/aoms.2015.48284
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发表时间：
2016-02-01
期刊：
影响因子：
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通讯作者：
Opolski G
中科院分区：
文献类型：
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作者：
Kiliszek M;Kozluk E;Franaszczyk M;Lodzinski P;Piatkowska A;Ploski R;Opolski G
肺静脉隔离（PVI）治疗心房颤动（AF）的疗效已得到充分证明。几个单核苷酸多态性（SNPs）与AF相关，主要在4q25位点，但也在16q22和1q21位点。我们研究的目的是测试这些snp与PVI的短期和长期结果之间的关系。在2006年至2009年间接受PVI治疗的房颤患者被纳入研究。肺静脉隔离采用4mm非冲洗消融导管、圆形测图导管和LocaLisa系统。所有患者均对4q25、16q22和1q21 snp进行基因分型。纳入238例患者。中位随访时间为45个月。6个月有效率为59.7%。在单变量分析中，没有任何多态性与6个月后房颤复发的风险相关。多因素分析中，rs2200733在隐性模型中与房颤复发显著相关（优势比1.87,p = 0.008）。在长期随访中，没有任何多态性预测房颤复发。在短期（6个月）随访中，rs2200733多态性TT基因型与PVI后房颤复发率增高有一定的关系趋势。在长期随访中，检测到的SNPs 4q25、16q22和1q21均与单次房颤消融的结果无关。
The efficacy of pulmonary vein isolation (PVI) in atrial fibrillation (AF) is well documented. Several single nucleotide polymorphisms (SNPs) are associated with AF, mainly in the 4q25 locus, but also in 16q22 and 1q21. The aim of our study was to test the association between those SNPs and short- and long-term results of PVI. Patients with AF who underwent PVI between 2006 and 2009 were included in the study. Pulmonary vein isolation was performed using a 4-mm non-irrigated ablation catheter, circular mapping catheter, and the LocaLisa system. All patients were genotyped for the 4q25, 16q22, and 1q21 SNPs. Two-hundred and thirty-eight patients were included. The median follow-up was 45 months. Six-month efficacy was 59.7%. None of the polymorphisms was linked with the risk of AF recurrence after 6 months in univariate analysis. In multivariate analysis rs2200733 in the recessive model was linked significantly with AF recurrence (odds ratio 1.87, p = 0.008). None of the polymorphisms predicted AF recurrence in long-term follow-up. There is a trend in the relationship between TT genotype of the rs2200733 polymorphism and increased rate of AF recurrence after PVI in short-term (6 months) follow-up. None of the tested SNPs 4q25, 16q22, and 1q21 correlated with the results of a single AF ablation in long-term follow-up.