MicroRNA dysregulation in multiple sclerosis.
MicroRNA dysregulation in multiple sclerosis.
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DOI：
10.3389/fgene.2012.00311
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发表时间：
2012
影响因子：
3.7
通讯作者：
Dhaunchak AS
中科院分区：
文献类型：
--
作者：
de Faria O Jr;Moore CS;Kennedy TE;Antel JP;Bar-Or A;Dhaunchak AS
多发性硬化症（MS）是一种以中枢神经系统（CNS）脱髓鞘和轴突变性为特征的慢性炎症性疾病。虽然MS的病因尚不清楚，但人们普遍认为，新型药物靶点需要同时关注减少炎症和促进CNS修复。在MS和实验性自身免疫性脑脊髓炎中，非编码小微RNA（miRNA）在免疫系统和CNS中失调。由于单个miRNA能够下调多个靶mRNA转录物，因此即使miRNA表达的微小变化也可能导致基因表达的显著改变。在此，我们回顾了MS患者CNS组织和免疫细胞中报道的miRNA特征，并考虑改变miRNA表达如何影响MS病理。
Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) demyelination and axonal degeneration. Although the cause of MS is still unknown, it is widely accepted that novel drug targets need to focus on both decreasing inflammation and promoting CNS repair. In MS and experimental autoimmune encephalomyelitis, non-coding small microRNAs (miRNAs) are dysregulated in the immune system and CNS. Since individual miRNAs are able to down-regulate multiple targeted mRNA transcripts, even minor changes in miRNA expression may lead to significant alterations in gene expression. Herein, we review miRNA signatures reported in CNS tissue and immune cells of MS patients and consider how altered miRNA expression may influence MS pathology.