The management of Helicobacter pylori infection and prevention and control of gastric cancer in China.
The management of Helicobacter pylori infection and prevention and control of gastric cancer in China.
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中国幽门螺杆菌感染的管理与胃癌的防控
DOI：
10.3389/fcimb.2022.1049279
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发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
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作者：
幽门螺杆菌（H. pylori感染与胃癌的发生密切相关。成功根除H. pylori感染可降低胃癌的发病率。我国是胃癌高发国家，H.幽门感染全世界近一半的胃癌新发病例和死亡归因于H。pylori感染发生在中国。H.幽门螺杆菌感染率随社会经济地位和卫生条件的改善而变化。及时掌握细菌耐药率，对指导临床合理选用抗菌药物有重要意义。随着中国五份关于H. pylori感染和公众宣传H.幽门螺杆菌相关知识、H.提高了临床医生对pylori的诊断和治疗水平。含铋四联疗法在H.幽门螺杆菌根除，因为高疗效和安全性。高剂量质子泵抑制剂-阿莫西林双联治疗或沃诺拉赞-阿莫西林双联治疗显示出与含铋四联治疗相当的疗效和较低的副作用，后者是替代选择。早期胃癌的诊断率较低，鉴别中国胃癌高危人群对进一步内镜筛查有重要意义。在中国GC风险人群中，已经建立了预测模型来分层GC风险。回顾了H.中国幽门螺杆菌感染与胃癌的预防和控制。
Helicobacter pylori (H. pylori) infection, a type-1 carcinogen, was closely associated with gastric cancer (GC). Successfully eradicating H. pylori infection could reduce the incidence of GC. China was a country with high incidence of GC and high prevalence of H. pylori infection. Nearly half of worldwide GC new cases and deaths attributed to H. pylori infection occurred in China. H. pylori prevalence varied over time with the improvement of socioeconomic status and sanitary conditions. The knowledge of antibiotic resistance rate in time was important to guide the clinical choice of antibiotics use in the regimens. With the publication of five Chinese consensus reports on the management of H. pylori infection and the effort of public preach of H. pylori-related knowledge, the standardization of H. pylori diagnosis and treatment by clinicians was improved. Bismuth-containing quadruple therapy was widely applied in clinical practice of H. pylori eradication because of high efficacy and safety. High-dose Proton Pump Inhibitor-amoxicillin dual therapy or vonoprazan-amoxicillin dual therapy showed comparable efficacy and lower side effects than bismuth-containing quadruple therapy, which were the alternative choice. The diagnosis rate of early GC was low and distinguishing Chinese GC risk population for the further endoscopy screening was important. Efforts have been done to establish prediction models to stratify GC risk in the Chinese GC risk population. We reviewed the current situation of the management of H. pylori infection and prevention and control of GC in China here.