Maternal Corticotropin-Releasing Hormone and the Use of Selective Serotonin Reuptake Inhibitors Independently Predict the Occurrence of Preterm Birth
Maternal Corticotropin-Releasing Hormone and the Use of Selective Serotonin Reuptake Inhibitors Independently Predict the Occurrence of Preterm Birth
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DOI：
10.1111/j.1542-2011.2010.00023.x
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发表时间：
2011-03-01
影响因子：
2.7
通讯作者：
Ruiz, Roberta Jeanne
中科院分区：
文献类型：
--
作者：
Latendresse, Gwen;Ruiz, Roberta Jeanne
研究方法：一项对100名孕妇进行的前瞻性队列研究包括慢性母体压力和促肾上腺皮质激素释放激素（CRH）的影响因素。人口统计学和行为数据包括吸烟，物质使用，和使用药物治疗抑郁症和anxiety.Results：孕妇谁使用SSRIs治疗抑郁症和/或焦虑症的近12倍，更有可能在足月前分娩的妇女相比，谁不使用这些药物。CRH水平在第四个四分位数的妇女在足月前分娩的可能性是CRH水平在下三个四分位数的妇女的6倍。SSRI的使用和CRHlevel.Discussion之间没有发现关联：PTB和母亲使用SSRI之间的关联尚不清楚。重要的是，在没有与女性充分讨论各种治疗方案的潜在益处和危害的情况下，不要改变目前治疗抑郁症和焦虑症的方法。
Methods: A prospective cohort study of 100 pregnant women included measures of contributors to chronic maternal stress and corticotropin-releasing hormone (CRH). Demographic and behavioral data included smoking, substance use, and use of medications for depression and anxiety.Results: Pregnant women who used SSRIs to treat depression and/or anxiety were nearly 12 times more likely to give birth before term when compared with women who did not use these medications. Women with CRH levels in the fourth quartile were 6 times more likely to give birth before term when compared with women whose CRH levels were in the lower 3 quartiles. No associations were found between SSRI use and CRH levels.Discussion: Associations between PTB and maternal use of SSRIs are not understood. It is important not to alter current approaches to the treatment of depression and anxiety without thorough discussion with women regarding the potential benefits and harms of various treatment options.