Nutrition in early life and risk of childhood leukemia: a case-control study in Greece
Nutrition in early life and risk of childhood leukemia: a case-control study in Greece
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DOI：
10.1007/s10552-012-0097-5
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发表时间：
2013-01-01
影响因子：
2.3
通讯作者：
Petridou, Eleni
中科院分区：
文献类型：
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作者：
Diamantaras, Andreas-Antonios;Dessypris, Nick;Petridou, Eleni
关于饮食在儿童白血病发生中的作用的研究结果很少，而关于检查的食物项目的研究结果是模棱两可的。这项病例对照研究调查了希腊5-14岁儿童的食物类型、常量营养素摄入量、总能量摄入量和坚持地中海饮食与儿童白血病的关系。共有139例连续的、偶发的白血病病例，其中121例为急性淋巴细胞白血病，来自全国儿童血液系统恶性肿瘤登记处沿着：一个年龄和性别匹配的医院对照组。通过与监护人/儿童的面对面访谈，获得了关于社会人口统计学、母婴变量和饮食习惯的信息。校正出生体重和可能的混杂变量后，进行多因素logistic回归分析，发现高血脂摄入与儿童白血病风险增加相关，而牛奶和乳制品摄入与风险降低相关。从常量营养素分析中，观察到一个临界趋势，将高蛋白质摄入量与儿童白血病风险降低联系起来。在生命的第一年食用牛奶和乳制品可能通过维生素D作用预防儿童白血病，而添加的脂质可能通过各种机制增加风险。这些结果为儿童的营养提供了一个全面的评估，并表明生命早期的饮食习惯可能有助于预防儿童白血病。
There is a paucity of findings concerning the role of diet in childhood leukemogenesis, whereas the results are equivocal and the studies heterogeneous with regard to food items examined. This case-control study investigates the association of childhood leukemia with food groups, macronutrient consumption, total energy intake and adherence to Mediterranean diet among children aged 5-14 years in Greece.A total of 139 consecutive, incident leukemia cases out of which 121 were acute lymphoblastic leukemia were derived from the Nationwide Registry for Childhood Hematological Malignancies along with one : one age- and gender-matched hospital controls. Information on socio-demographic, maternal and child variables and dietary habits was obtained through in-person interviews with the guardians/children. Multiple logistic regression was performed with adjustment for birth weight and possible confounding variables.Higher consumption of added lipids was associated with an increased risk of childhood leukemia, whereas consumption of milk and dairy products with reduced risk. From the macronutrient analysis, a borderline trend linking high protein intake with reduced childhood leukemia risk was observed.Consumption of milk and dairy products in the first year of life may protect against childhood leukemia possibly through vitamin D actions, while added lipids may increase the risk through various mechanisms. These results offer a holistic evaluation of children's nutrition and suggest that dietary habits in the early years of life may contribute to the prevention of childhood leukemia.