Modulation of neural response to happy and sad faces by acute tryptophan depletion
Modulation of neural response to happy and sad faces by acute tryptophan depletion
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DOI：
10.1007/s00213-007-0757-4
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发表时间：
2007-07-01
影响因子：
3.4
通讯作者：
McGuire, Philip K.
中科院分区：
文献类型：
--
作者：
Fusar-Poli, Paolo;Allen, Paul;McGuire, Philip K.
研究背景中枢5-羟色胺（centralserotonin，5 HT）在情绪加工中起重要作用。本研究采用功能性神经影像学（fMRI）技术，探讨了实验性调控中枢5-HT水平对快乐和悲伤面部表情反应的影响。（8名男性和2名女性）在接受无干扰的情绪处理任务后，结果ATD可使血浆总色氨酸浓度降低80%。对主观情绪评分、反应准确性和反应时间没有显著影响。与假耗竭相比，ATD减弱了右侧内侧/额下回、后扣带回皮质、双侧枕叶和顶叶皮质、右侧海马、屏状核和海马的激活。相反，ATD与左额下回相对增加的激活相关。ATD对右侧壳核和左侧上级颞回的情绪面孔加工过程中的激活有不同的影响。结论在皮层和皮层下区域，ATD引起的5 HT操作对情绪面孔加工相关的神经反应有显著的调制作用。此外，在某些领域，5-HT的这种作用取决于刺激的情绪效价。
Background Central serotonin (5HT) plays a major role in emotional processing. We used functional neuroimaging (fMRI) to investigate the effects of experimental manipulation of central 5HT levels on the regional neural response to happy and sad facial expressions.Methods Ten healthy participants (eight men and two women) were scanned during an implicit emotional processing task after receiving a tryptophan-free (acute tryptophan depletion, ATD) or a balanced amino acid drink in a double-blind design.Results ATD lowered total plasma tryptophan concentration by 80%. There was no significant effect on subjective mood ratings, on response accuracy and on reaction times. Compared to sham depletion, ATD attenuated activation in the right medial/inferior frontal gyrus, the posterior cingulate cortex, the occipital and parietal cortex bilaterally, the right hippocampus, claustrum and insula. Conversely, ATD was associated with relatively increased activation in the left inferior frontal gyrus. ATD had differential effects on activation during the processing of happy and sad faces in the right putamen and in the left superior temporal gyrus.Conclusions In both cortical and sub-cortical regions, the neural response associated with processing emotional faces is significantly modulated by 5HT manipulation resulting from ATD. Moreover, in certain areas, this effect of 5HT depends on the emotional valence of the stimulus.