Unusual Metastatic Patterns of Invasive Lobular Carcinoma of the Breast
Unusual Metastatic Patterns of Invasive Lobular Carcinoma of the Breast
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DOI：
10.1155/2013/986517
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发表时间：
2013-01-01
影响因子：
0.9
通讯作者：
Connolly, Mark M.
中科院分区：
文献类型：
--
作者：
Sobinsky, Justin D.;Willson, Thomas D.;Connolly, Mark M.
与浸润性导管癌相比，乳腺浸润性小叶癌具有相似的转移模式；然而，小叶癌更容易转移到不寻常的部位。我们报告了一位65岁的女性，她患有侵袭性小叶性乳腺癌（T3N3M0），接受了改良的根治性乳房切除术和芳香酶抑制剂治疗，她接受了监视PET扫描，显示可能是乙状结肠癌。结肠镜活检显示一个3厘米的乙状结肠腺癌。患者接受了下前部切除术。病理表现为溃疡性侵袭性中分化腺癌，并延伸至肌固有层，但未穿过肌固有层。然而，17个结肠旁淋巴结中有6个转移性乳腺癌阳性（ER+/PR+），与她的小叶原发性乳腺癌一致；没有转移性结肠癌的证据。本病例突出了小叶癌不寻常的转移模式。
Invasive lobular carcinoma of the breast has similar patterns of metastatic disease when compared to invasive ductal carcinoma; however, lobular carcinoma metastasizes to unusual sites more frequently. We present a 65-year-old female with a history of invasive lobular breast carcinoma (T3N3M0) treated with modified radical mastectomy and aromatase-inhibitor therapy who underwent a surveillance PET scan, which showed possible sigmoid cancer. Colonoscopy with biopsy revealed a 3 cm sigmoid adenocarcinoma. The patient underwent a lower anterior resection. Pathology showed an ulcerated, invasive moderately differentiated adenocarcinoma extending into but not through the muscular is propria. However, six of seventeen paracolonic lymph nodes were positive for metastatic breast carcinoma (ER+/PR+), consistent with her lobular primary breast carcinoma; there was no evidence of metastatic colon cancer. This case highlights the unusual metastatic patterns of lobular carcinoma.