Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase
Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase
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DOI：
10.1089/hum.1998.9.6-801
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发表时间：
1998-04-10
影响因子：
4.2
通讯作者：
Shewach, DS
中科院分区：
文献类型：
--
作者：
Boucher, PD;Ruch, RJ;Shewach, DS
稳定表达单纯疱疹病毒胸苷激酶（HSV-TK）的两株人结肠癌细胞系HT-29和SW 620对抗病毒药物更昔洛韦（GCV）的细胞毒作用敏感，与HT-29细胞相比，SW 620细胞对较低浓度的GCV更敏感。
The two human colon carcinoma cell lines HT-29 and SW620, which stably express herpes simplex virus thymidine kinase (HSV-TK), are sensitized to the cytotoxic effects of the antiviral drug ganciclovir (GCV), Compared with HT-29 cells, SW620 cells ware more sensitive to lower GCV concentrations (