The role of long non-coding RNAs in the pathogenesis of head and neck squamous cell carcinoma.
The role of long non-coding RNAs in the pathogenesis of head and neck squamous cell carcinoma.
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长链非编码RNA在头颈鳞状细胞癌发病机制中的作用
DOI：
10.1016/j.omto.2021.12.001
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发表时间：
2022-03-17
期刊：
影响因子：
--
通讯作者：
Zhang R
中科院分区：
文献类型：
--
作者：
Jiang M;Liu F;Yang AG;Wang W;Zhang R
头颈部肿瘤是上呼吸道、唾液腺和甲状腺恶性肿瘤的异质集合。然而，头颈部鳞状细胞癌（HNSCCs）发生的分子机制仍然知之甚少。在过去的几十年里，大量的证据表明长链非编码rna （lncRNAs）在包括HNSCC在内的肿瘤发生中的调节作用。值得注意的是，这些lncrna在基因调控中起着至关重要的作用，并影响细胞稳态的各个方面，包括增殖、存活和转移。它们通过与核酸或蛋白质相互作用，影响癌细胞信号传导，发挥调节作用。lncrna代表了一个新兴的癌症研究领域，我们才刚刚开始了解lncrna在HNSCC中的重要性和同谋性。本文就lncrna在HNSCC中的调控作用及功能进行综述。我们还综述了lncRNAs在HNSCC发病机制中的作用机制，并讨论了lncRNAs作为诊断/预后工具和治疗靶点在人类HNSCC中的潜在应用。头颈部鳞状细胞癌（HNSCC）是一种主要的恶性疾病。在这里，我们总结了lncrna （200-nt - 100 kb转录本缺乏蛋白质编码电位）在HNSCC中的失调和功能障碍，回顾了它们在HNSCC发病中的作用机制，并讨论了它们作为诊断/预后工具和治疗靶点的潜在应用。
Head and neck cancers are a heterogeneous collection of malignancies of the upper aerodigestive tract, salivary glands, and thyroid. However, the molecular mechanisms underlying the carcinogenesis of head and neck squamous cell carcinomas (HNSCCs) remain poorly understood. Over the past decades, overwhelming evidence has demonstrated the regulatory roles of long non-coding RNAs (lncRNAs) in tumorigenesis, including HNSCC. Notably, these lncRNAs have vital roles in gene regulation and affect various aspects of cellular homeostasis, including proliferation, survival, and metastasis. They exert regulating functions by interacting with nucleic acids or proteins and affecting cancer cell signaling. LncRNAs represent a burgeoning field of cancer research, and we are only beginning to understand the importance and complicity of lncRNAs in HNSCC. In this review, we summarize the deregulation and function of lncRNAs in human HNSCC. We also review the working mechanism of lncRNAs in HNSCC pathogenesis and discuss the potential application of lncRNAs as diagnostic/prognostic tools and therapeutic targets in human HNSCC. Head and neck squamous cell carcinoma (HNSCC) is a leading malignant disease. Here, we summarize the deregulation and dysfunction of lncRNAs (200-nt to 100-kb transcripts lacking protein-coding potentials) in HNSCC, review their working mechanism in HNSCC pathogenesis, and discuss their potential application as diagnostic/prognostic tools and therapeutic targets.
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