Natural killer cells wear different hats: effector cells of innate resistance and regulatory cells of adaptive immunity and of hematopoiesis.
Natural killer cells wear different hats: effector cells of innate resistance and regulatory cells of adaptive immunity and of hematopoiesis.
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DOI：
10.1006/smim.1995.0012
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发表时间：
1995-04-01
影响因子：
7.8
通讯作者：
Trinchieri, G
中科院分区：
文献类型：
--
作者：
Trinchieri, G
自然杀伤（NK）细胞最初被定义为具有裂解肿瘤细胞或病毒感染细胞的能力，并被鉴定为一类非抗原特异性先天性抗性的效应细胞。然而，最近的许多研究拓宽了NK细胞在免疫中的作用的解释，并表明NK细胞在先天性抵抗、抗原特异性获得性免疫以及可能在造血中具有重要的调节作用。NK细胞的这些功能不仅仅取决于它们的细胞毒性活性，可能还取决于它们产生淋巴因子，特别是干扰素-γ（IFN-γ）的能力。NK细胞对于感染早期吞噬细胞的抗原非依赖性活化和有利于产生IFN-γ和IL-2的I型抗原特异性T辅助细胞的发育是重要的。NK细胞在抑制造血和诱导感染性休克中的作用可能代表了NK细胞在先天抵抗中生理功能的病理性夸大。
Natural killer (NK) cells were originally defined by their ability to lyse tumor cells or virus-infected cells and identified as one type of effector cells of the non-antigen specific innate resistance. However, many recent studies have widened the interpretation of the role of NK cells in immunity and shown that NK cells have important regulatory roles in innate resistance, antigen-specific adaptive immunity, and, possibly, in hematopoiesis. These functions of NK cells more than on their cytotoxic activity, are probably dependent on their ability to produce lymphokines, particularly interferon-gamma (IFN-gamma). NK cells are important for antigen-independent activation of phagocytic cells early in infection and for favoring the development of antigen-specific T helper cells type I, producing IFN-gamma and IL-2. A role for NK cells in suppression of hematopoiesis and in induction of septic shock may represent a pathological exaggeration of the physiologic functions of NK cells in innate resistance.