High plasma adenine concentration in chronic renal failure and its relation to erythrocyte ATP
High plasma adenine concentration in chronic renal failure and its relation to erythrocyte ATP
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DOI：
10.1159/000058406
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发表时间：
2002-06-01
期刊：
影响因子：
2.5
通讯作者：
Swierczynski, J
中科院分区：
文献类型：
--
作者：
Slominska, EM;Szolkiewicz, M;Swierczynski, J
背景血浆腺嘌呤浓度在慢性肾功能衰竭（CRF）时升高。本研究的目的是评估高血浆腺嘌呤浓度是否有助于CRF患者红细胞ATP升高。研究方法：研究了三组CRF患者：（A）30例不同程度的CRF患者;（13）11例血液透析患者;（C）12例成功的肾移植患者。测定A、B、C组血浆腺嘌呤和红细胞腺嘌呤核苷酸浓度。同时测定A组红细胞腺嘌呤核苷酸库的腺嘌呤掺入量。结果如下：CRF患者血浆腺嘌呤浓度与肌酐浓度、红细胞ATP浓度呈正相关。红细胞腺嘌呤核苷酸库掺入率与CRF严重程度呈正相关。血液透析后立即观察到血浆腺嘌呤和红细胞ATP的显着降低，但2天后，高透析前血浆腺嘌呤和红细胞ATP浓度恢复。肾移植成功后，红细胞ATP和血浆腺嘌呤浓度达到对照值。结论：我们的研究结果提供了证据表明，血浆腺嘌呤浓度增加平行于疾病的进展，它可能是负责与慢性肾功能衰竭患者红细胞ATP的增加。版权所有（C）2002 S. KargerAG，巴塞尔。
Background. Concentration of plasma adenine has been found to increase in chronic renal failure (CRF). The aim of the present study was to evaluate whether high plasma adenine concentration contributes to the elevated ATP in erythrocytes of patients with CRF. Methods: Three groups of patients with CRF were studied: (A) 30 patients with different degree of CRF; (13) 11 patients on hemodialysis, and (C) 12 patients after successful renal transplantation. Concentrations of plasma adenine and erythrocyte adenine nucleotides were measured in groups A, B and C. Furthermore, adenine incorporation into erythrocyte adenine nucleotide pool was measured in group A. Results: A positive correlation between plasma adenine and creatinine concentrations was found in CRF as well as between plasma adenine and erythrocyte ATP. Furthermore, positive correlation was evident between the rate of adenine incorporation into erythrocyte adenine nucleotide pool and the severity of CRF. A significant reduction in both plasma adenine and erythrocyte ATP was observed immediately following hemodalysis, but 2 days later, high predialysis plasma adenine and erythrocyte ATP concentrations were restored. Following successful renal transplantation erythrocyte ATP and plasma adenine concentrations reached control values. Conclusion: Our results provide evidence that plasma adenine concentration increases in parallel to the progress of the disease and that it could be responsible for the increase in erythrocyte ATP of patients with CRF. Copyright (C) 2002 S. KargerAG, Basel.