Studies on nicotine biosynthesis.
Studies on nicotine biosynthesis.
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尼古丁生物合成研究。
DOI：
10.1021/ja01096a032
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发表时间：
1965
影响因子：
15
通讯作者：
G. Waller
中科院分区：
文献类型：
--
作者：
K. S. Yang;R. Gholson;G. Waller
本文报道了一种逐步降解尼古丁吡啶环的方法，包括尼古丁氧化为烟酸，烟酸生物转化为蓖麻碱，蓖麻碱化学降解。使用这种降解方法，已经表明甘油被掺入尼古丁吡啶环的碳4、5和6中而没有随机化。这种降解方法也被用来证实在尼古丁生物合成过程中烟酸的吡啶环与吡咯烷环的融合机制，这是Dawson等人先前提出的
A method for the stepwisedegradation of the pyridine ring of nicotine has been developedwhich involves the oxidation of nicotine to nicotinic acid, the biological conversion of nicotinic acid to ricinine, and the chemical degradation of ricinine. Using this degradation method it has been shown that glycerol is incorporated without randomization into carbons 4, 5, and 6 of the pyridine ring of nicotine. This degradation method has alsobeen used to confirm the mechanism of fusion of the pyridine ring of nicotinic acid with the pyrrolidine ring during nicotine biosynthesis, previously proposed by Dawson, et