Review of clinical practice utility of positron emission tomography with 18F-fluorodeoxyglucose in assessing tumour response to therapy.
Review of clinical practice utility of positron emission tomography with 18F-fluorodeoxyglucose in assessing tumour response to therapy.
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DOI：
10.1007/s11547-014-0446-4
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发表时间：
2015-04
影响因子：
8.9
通讯作者：
d'Amico, Andrea
中科院分区：
文献类型：
--
作者：
d'Amico, Andrea
正电子发射断层扫描，最常见的是18F-氟代脱氧葡萄糖，正被用于评估肿瘤对治疗的反应。该方法的局限性与(1)氟脱氧葡萄糖的药代动力学性质、(2)检测系统、(3)代谢图像和解剖图像之间的差异以及(4)采集标准化有关。对治疗的反应可用定性方法(多维尔评分)、半定量方法(标准化摄取值)和定量方法(欧洲癌症研究和治疗组织；实体肿瘤正电子发射断层扫描反应标准)进行评估。接受评估的方法包括代谢性肿瘤体积、总病变糖酵解和氟脱氧葡萄糖摄取的异质性。具有更大视野的正电子发射断层扫描仪的发展可能有助于基于动力学模型的肿瘤评估。这些方法的更多临床应用将取决于直观和简单的分析工具的开发和验证。
Positron emission tomography, most commonly with 18F-fluorodeoxyglucose, is being used for evaluation of tumour response to therapy. Limitations of this method are associated with (1) fluorodeoxyglucose pharmacokinetic properties, (2) the detection system, (3) discrepancies between metabolic and anatomic images, and (4) acquisition standardization. Response to therapy may be evaluated with qualitative (Deauville score), semiquantitative (standardised uptake value), and quantitative methods (European Organization for Research and Treatment of Cancer; Positron Emission Tomography Response Criteria in Solid Tumours). Methods under evaluation include metabolic tumour volume, total lesion glycolysis, and heterogeneity of fluorodeoxyglucose uptake. The development of positron emission tomography scanners that have larger fields of view may facilitate tumour assessment based on kinetic modelling. Increased clinical use of these methods will depend on the development and validation of intuitive and simple analytic tools.
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影响因子：
4.9
作者：
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DOI：
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发表时间：
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