Cognitive and motor deficits in the acquisition of an object retrieval/detour task in MPTP-treated monkeys.
Cognitive and motor deficits in the acquisition of an object retrieval/detour task in MPTP-treated monkeys.
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DOI：
10.1093/brain/113.3.617
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发表时间：
1990-06
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影响因子：
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通讯作者：
JaneR . Taylor;J. Elsworth;R. Roth;J. Sladek;D. Redmond
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文献类型：
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作者：
JaneR . Taylor;J. Elsworth;R. Roth;J. Sladek;D. Redmond
为了评估1-甲基-4-苯基-1，2，3，6-四氢吡啶(MPTP)治疗后猴子的功能变化，我们研究了一项揭示在不同条件下对多巴胺缺乏敏感的任务。这项任务需要从一边打开并固定在托盘上的透明盒子中取出一片香蕉片。成功的表演需要被试抑制直接触及奖赏的倾向，同时(1)打开一侧的方向，(2)托盘上的位置，(3)香蕉在盒子里的位置，以改变试验的认知和运动难度。用MPTP(1.5~1.6 mg/kg)连续4~5天给非洲绿猴(Cercopithecus AtheiopsSabaeus)灌胃。对照组为假手术组(n=12)。接受MPTP治疗的受试者要么出现严重的症状，表现出阻碍他们行动的运动障碍，要么没有表现出严重的运动障碍(n=6)，尽管多巴胺浓度严重耗尽。接受MPTP治疗的受试者在8-12个月后的测试中表现出对任务的习得能力受损。他们在实验过程中犯了更多错误，特别是在与认知复杂性有关的试验中，比如试图通过盒子的透明一侧直接到达奖励(障碍到达)，而不是绕过它(绕道到达)到开放的一侧，以及其他笨拙、持久或延迟的到达。MPTP似乎会在治疗后8-12个月内导致认知和运动障碍，即使在从未表现出严重运动障碍的猴子组中也是如此。
To assess functional changes following treatment with 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) in monkeys, we studied a task that reveals sensitivity to dopamine deficits under various conditions. The task required retrieval of a banana slice from a transparent box that is open on one side and fastened to a tray. Successful performance required the subject to suppress a tendency to reach directly at the reward while (1) orientation of the open side, (2) position on the tray, and (3) position of the banana in the box were manipulated in order to vary the cognitive and motor difficulty of the trial. African green monkeys (Cercopithecus aethiops sabaeus) were treated with MPTP (1.5-1.6 mg/kg cumulative dose over 4-5 days). A control group was sham treated (n = 12). MPTP-treated subjects either became severely symptomatic, showing motor impairments that prevented them from performing, or showed no gross motor impairment (n = 6) in spite of major depletions in dopamine concentrations. MPTP-treated subjects showed impaired acquisition of the task when tested 8-12 months later. They made more errors during the sessions, specifically on the trials that were related to cognitive complexity, such as attempting to reach directly towards the reward through the transparent side of the box (a barrier reach), instead of reaching around it (detour) into the open side, as well as other awkward, perseverative or delayed reaches. MPTP appears to cause both cognitive and motor deficits in the acquisition of this task 8-12 months after treatment, even in the group of monkeys which never showed gross motor deficits.