EFFECTS OF DIETS RICH IN MONOUNSATURATED FATTY-ACIDS ON PLASMA-LIPOPROTEINS - THE JERUSALEM NUTRITION STUDY - HIGH MUFAS VS HIGH PUFAS
EFFECTS OF DIETS RICH IN MONOUNSATURATED FATTY-ACIDS ON PLASMA-LIPOPROTEINS - THE JERUSALEM NUTRITION STUDY - HIGH MUFAS VS HIGH PUFAS
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DOI：
10.1093/ajcn/53.4.899
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发表时间：
1991-04-01
影响因子：
7.1
通讯作者：
STEIN, Y
中科院分区：
文献类型：
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作者：
BERRY, EM;EISENBERG, S;STEIN, Y
26名Yeshiva学生被随机分配到一个24周的交叉研究，单不饱和脂肪酸（MUFA）与多不饱和脂肪酸（PUFA）饮食（50%碳水化合物，32%脂肪，18%蛋白质）在两个12周的期间交替喂养。 总血浆胆固醇（TC）显着降低约10%和约16%的MUFA和PUFA饮食，分别。 血浆甘油三酯反应是可变的。 两组的低密度脂蛋白胆固醇（LDL-C）均降低，并且在两个阶段之间具有额外的显著影响。 高密度脂蛋白胆固醇的浓度没有显著变化。 新鲜单核细胞的LDL受体状态，培养的成纤维细胞的LDL受体的亲和力，区域离心配置文件，和脂蛋白的组成之间的饮食没有显着差异。 PUFA饮食中脂质过氧化的趋势显着更高，这一点通过该饮食中形成更多硫代巴比妥酸反应物质来确定。 膳食PUFA导致TC和LDL-C浓度略低，而MUFA则降低了LDL对氧化应激的敏感性。
Twenty-six Yeshiva students were randomly assigned to a 24-wk crossover study of monounsaturated fatty acid (MUFA) vs polyunsaturated fatty acid (PUFA) diets (50% carbohydrate, 32% fat, 18% protein) fed alternately during two 12-wk periods. Total plasma cholesterol (TC) decreased significantly by approximately 10% and approximately 16% on the MUFA and PUFA diets, respectively. Plasma triglyceride response was variable. Low-density-lipoprotein cholesterol (LDL-C) decreased in both groups with an additional significant effect between periods. Concentrations of high-density-lipoprotein cholesterol did not change significantly. LDL-receptor status in fresh monocytes, affinity of LDL towards the LDL receptor in cultured fibroblasts, zonal-centrifugation profiles, and lipoprotein composition were not significantly different between the diets. There was a significantly higher tendency toward lipid peroxidation on the PUFA diet, as ascertained by more thiobarbituric acid-reactive-substances formation on that diet. Dietary PUFA results in somewhat lower TC and LDL-C concentrations whereas with MUFA the susceptibility of LDL to oxidative stress is lower.