Granulomatous keratic precipitates in birdshot retinochoroiditis
Granulomatous keratic precipitates in birdshot retinochoroiditis
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DOI：
10.1007/s10792-012-9650-1
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发表时间：
2013-04-01
影响因子：
1.6
通讯作者：
Herbort, Carl P.
中科院分区：
文献类型：
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作者：
Knecht, Pascal B.;Papadia, Marina;Herbort, Carl P.
为了促进这种罕见疾病的临床研究，一个专家小组公布了鸟射性视网膜脉络膜炎(RCBRC)的研究标准。我们研究的目的是调查RCBRC的排除标准适用于本中心所有诊断为BRC的患者的敏感性。这是一项单中心的回顾性研究，涉及1995至2012年间在瑞士洛桑眼科专科护理中心就诊的所有眼炎性疾病患者。确定被诊断为BRC的患者的百分比。所有患者均采用RCBRC的排除标准，计算无角膜沉淀物(KPS)和无后粘连患者的百分比。在1,504名新患者中，25名患者(1.66%；19名女性，6名男性)被诊断为BRC，19名患者有足够的数据纳入研究(1.26%，13名女性)。所有患者的HLA-A29检测均为阳性。RCBRC对排除标准适用于我们的患者队列的敏感性为84.2%，这是因为排除了三名表现为KPS的患者。我们的研究支持重新评估RCBRC的动议，因为肉芽肿性KPS可能存在，而且比先前估计的更频繁，严格应用标准将导致研究患者的大量损失。
With the purpose of facilitating clinical studies of this infrequent disease, an expert panel published research criteria for birdshot retinochoroiditis (RCBRC). The aim of our study was to investigate the sensitivity of the exclusion criteria of the RCBRC as applied to all patients seen in our center with a diagnosis of BRC. This was a single center retrospective study involving all patients with an ocular inflammatory disease seen at the Centre for Ophthalmic Specialized Care, Lausanne, Switzerland, between 1995 and 2012. The percentage of patients with a diagnosis of BRC was identified. The exclusion criteria of the RCBRC were applied to all patients and the percentage of patients with absence of keratic precipitates (KPs) and absence of posterior synechiae were calculated. Out of 1,504 new patients, 25 patients (1.66 %; 19 female, 6 male) were diagnosed with BRC and 19 patients had sufficient data to be included in the study (1.26 %, 13 female). All patients were positive for HLA-A29 testing. The sensitivity of the RCBRC with respect to the exclusion criteria applied to our patient cohort was 84.2 % due to the exclusion of three patients showing KPs. Our study supports the motion to re-evaluate the RCBRC, since granulomatous KPs can be present and are more frequent than previously estimated and stringent application of the criteria would lead to a substantial loss of study patients.