INCREASED DERMAL MAST-CELL POPULATIONS IN PROGRESSIVE SYSTEMIC-SCLEROSIS - A LINK IN CHRONIC FIBROSIS
INCREASED DERMAL MAST-CELL POPULATIONS IN PROGRESSIVE SYSTEMIC-SCLEROSIS - A LINK IN CHRONIC FIBROSIS
复制标题
DOI：
10.7326/0003-4819-102-2-182
复制
发表时间：
1985-01-01
影响因子：
39.2
通讯作者：
STEIGERWALD, JC
中科院分区：
文献类型：
--
作者：
HAWKINS, RA;CLAMAN, HN;STEIGERWALD, JC
真皮胶原沉积是进行性系统性硬化症（硬皮病）早期硬结阶段的标志。这个过程往往在疾病的晚期阶段缓解。因为肥大细胞被认为参与纤维化过程的发展，皮肤肥大细胞群体的密度在硬皮病患者的一组临床受累和未受累皮肤中测量。硬皮病早期患者临床受累皮肤中的肥大细胞计数（111 . ±. 28 [SD]个细胞/mm 2）显著高于相同患者临床未受累皮肤中的那些（58 ± 28 [SD]个细胞/mm 2）。26个细胞/mm 2），也高于正常对照组（50 ± 0.26个细胞/mm 2）。14个细胞/mm 2）。晚期硬皮病患者临床受累和未受累皮肤的肥大细胞计数均正常。当肥大细胞密度通过真皮深度分析时，与对照组相比，早期硬皮病患者的受累乳头状真皮和受累网状真皮的肥大细胞密度分别增加了85%和152%。肥大细胞可能是重要的进行性系统性硬化症的早期皮肤病变的发病机制，可能通过促进纤维化。
Dermal collagen deposition is the hallmark of the early indurative phase of progressive systemic sclerosis (scleroderma). This process tends to remit in late stages of the disease. Because mast cells are believed to participate in the development of fibrotic processes, the density of the cutaneous mast cell population was measured in clinically involved and uninvolved skin of a group of patients with scleroderma. Mast cell counts in clinically involved skin of patients with early stages of scleroderma (111 .+-. 28 [SD] cells/mm2) were significantly greater than those in clinically uninvolved skin of the same patients (58 .+-. 26 cells/mm2) and also greater than those of normal controls (50 .+-. 14 cells/mm2). Mast cell counts in clinically involved and uninvolved skin of patients with late scleroderma were normal. When mast cell density was analyzed by depth of dermis, an 85% increase was noted in involved papillary dermis and a 152% increase in involved reticular dermis in patients with early scleroderma when compared with densities in controls. Mast cells may be important in the pathogenesis of the early cutaneous lesions of progressive systemic sclerosis, perhaps by promoting fibrosis.