Body mass index across adult life and cognitive function in the American elderly
Body mass index across adult life and cognitive function in the American elderly
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美国老年人成年后的体重指数和认知功能
DOI：
10.18632/aging.103209
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发表时间：
2020-05-31
期刊：
影响因子：
5.2
通讯作者：
Li, Shengxu
中科院分区：
文献类型：
--
作者：
Zhou, Yun;Zhang, Tao;Li, Shengxu
这项研究旨在研究2011-2014年NHANES中2，637名年龄在60岁或以上的参与者的成年生活中体重指数（BMI）与认知功能的关系。主要结果是基于单词列表学习、动物命名和数字符号替换的测试分数的综合分数。关注的暴露包括25岁时的BMI、调查前10年的BMI、调查时的BMI（当前BMI）和从25岁至调查时年龄计算的BMI负担。25岁时的BMI与综合评分呈负相关（β =-0.0271 +/-0.0130/kg/m2，P=0.038），与低认知能力呈正相关（比值比=1.04，95%置信区间：1.01-1.07，P=0.010），定义为低于综合评分的20百分位数。调查前10年的BMI和BMI负担也观察到类似的结果。当前BMI与综合评分呈正相关（β =0.0369 +/- 0.0113，P=0.001），与低认知能力呈负相关（比值比=0.96，95%置信区间：0.94-0.99，P=0.004）。总之，成年早期的高BMI与晚年的低认知功能相关，这强调了健康体重在整个生命过程中的重要性。BMI与晚年认知功能之间的关系需要进一步研究。
This study aimed to examine the associations of body mass index (BMI) across adult life with cognitive function in 2,637 participants aged 60 years or over from NHANES 2011-2014. The primary outcome was a composite score based on test scores on word list learning, animal naming, and digit symbol substitution. Exposures of interest included BMI at age 25, BMI 10 years before the survey, BMI at the survey (current BMI), and BMI burden calculated from age 25 to age at survey. BMI at age 25 was inversely associated with the composite score (beta=-0.0271 +/- 0.0130 per kg/m(2), P=0.038) and positively with low cognitive performance (odd ratio=1.04, 95% confidence interval: 1.01-1.07, P=0.010), defined as below 20 percentile of the composite score. Similar results were observed for BMI 10 years before the survey and BMI burden. Current BMI was positively associated with the composite score (beta=0.0369 +/- 0.0113, P=0.001) and inversely associated with low cognitive performance (odd ratio=0.96, 95% confidence interval: 0.94-0.99, P=0.004). In conclusion, high BMI in early adult life is associated with low cognitive function in late life, which underscores the importance of a healthy body weight across the life course. The association between BMI and cognitive function at late life requires further investigation.