Selective transition-metal-free vicinal cis-dihydroxylation of saturated hydrocarbons.
Selective transition-metal-free vicinal cis-dihydroxylation of saturated hydrocarbons.
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DOI：
10.1039/c6sc03055f
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发表时间：
2017-01-01
期刊：
影响因子：
8.4
通讯作者：
Antonchick AP
中科院分区：
文献类型：
--
作者：
Bering L;Antonchick AP
发展了一种在无过渡金属存在的条件下，通过双C（sp3）-H键功能化的烷烃选择性邻位双羟基化反应。发展了一种不含过渡金属的饱和烃顺式二羟基化反应。所描述的方法允许邻位二醇的直接和选择性合成。因此，新的反应通过自由基碘化和一系列氧化步骤进行。一锅双C（sp3）-H键功能化的邻位的顺式二醇的选择性合成的广泛范围被证明。
A selective vicinal dihydroxylation of alkanes by dual C(sp3)–H bond functionalization under transition-metal-free reaction conditions has been developed. A transition-metal-free cis-dihydroxylation of saturated hydrocarbons under ambient reaction conditions has been developed. The described approach allows a direct and selective synthesis of vicinal diols. The new reaction thereby proceeds via radical iodination and a sequence of oxidation steps. A broad scope of one-pot dual C(sp3)–H bond functionalization for the selective synthesis of vicinal syn-diols was demonstrated.