RNA Regulation of Lipotoxicity and Metabolic Stress.
RNA Regulation of Lipotoxicity and Metabolic Stress.
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DOI：
10.2337/db16-0147
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发表时间：
2016-07
期刊：
影响因子：
7.7
通讯作者：
Schaffer JE
中科院分区：
文献类型：
--
作者：
Caputa G;Schaffer JE
非编码RNA是一类新兴的非肽类代谢调节因子。代谢性疾病和代谢环境的改变诱导microRNA和长链非编码RNA水平的显著变化。此外，最近的研究表明，越来越多的microRNA和长的非编码RNA作为关键介质的适应性和适应不良反应，通过它们对基因表达的影响。代谢环境对非编码RNA的功能也有深远的影响，这些非编码RNA被认为主要在细胞中起管家作用，如核糖体RNA、转移RNA和小核仁RNA。越来越多的证据表明，这些RNA也是对代谢环境的综合细胞反应的组成部分。这一观点讨论了不同类别的非编码RNA及其对代谢应激发病机制的贡献。
Noncoding RNAs are an emerging class of nonpeptide regulators of metabolism. Metabolic diseases and the altered metabolic environment induce marked changes in levels of microRNAs and long noncoding RNAs. Furthermore, recent studies indicate that a growing number of microRNAs and long noncoding RNAs serve as critical mediators of adaptive and maladaptive responses through their effects on gene expression. The metabolic environment also has a profound impact on the functions of classes of noncoding RNAs that have been thought primarily to subserve housekeeping functions in cells—ribosomal RNAs, transfer RNAs, and small nucleolar RNAs. Evidence is accumulating that these RNAs are also components of an integrated cellular response to the metabolic milieu. This Perspective discusses the different classes of noncoding RNAs and their contributions to the pathogenesis of metabolic stress.