Sex-dependent effects of developmental exposure to bisphenol A and ethinyl estradiol on metabolic parameters and voluntary physical activity.
Sex-dependent effects of developmental exposure to bisphenol A and ethinyl estradiol on metabolic parameters and voluntary physical activity.
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DOI：
10.1017/s2040174415001488
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发表时间：
2015-12
影响因子：
1.7
通讯作者：
Rosenfeld CS
中科院分区：
文献类型：
--
作者：
Johnson SA;Painter MS;Javurek AB;Ellersieck MR;Wiedmeyer CE;Thyfault JP;Rosenfeld CS
内分泌干扰物(EDC)作为一种潜在的致肥性物质，受到了广泛的关注。过去检测一种广泛存在的EDC-双酚A(BPA)的肥胖潜力的研究通常集中在代谢和脂肪组织的影响上。然而，缺乏运动被认为是肥胖的主要原因。很少有研究考虑包括双酚A在内的EDC是否会影响这种行为。为了测试早期暴露于双酚A和乙烯基雌二醇(EE，避孕药中存在的雌激素)是否会导致代谢和此类行为紊乱，发育中暴露于BPA和EE的加州小鼠作为成年鼠接受了能量消耗(间接量热法)、身体成分(ECO MRI)和体力活动(通过光束断裂和自愿车轮跑步来测量)的测试。测定血糖和代谢激素水平。没有检测到体重或食物摄入量的差异。在对照组和EE组中，暴露于双酚A的女性的体重变化比女性更大。在黑暗和光照周期中，BPA雌性比对照雌性表现出更高的平均呼吸商，这表明代谢碳水化合物而不是脂肪。在家中对自愿身体活动的各种评估证实，在黑暗周期中，暴露于BPA和EE的雌性在这种环境中的活动明显低于对照雌性。在接触双酚A或EE的男性中没有观察到类似的影响。两组患者血糖、胰岛素、脂联素和瘦素水平无显著差异。结果表明，发育过程中暴露于双酚A的女性表现出从事自愿体育活动的动机降低，碳水化合物与脂肪的代谢发生变化，这可能对健康有重要影响。
Endocrine disrupting chemicals (EDC) have received considerable attention as potential obesogens. Past studies examining obesogenic potential of one widespread EDC, bisphenol A (BPA), have generally focused on metabolic and adipose tissue effects. However, physical inactivity has been proposed to be a leading cause of obesity. A paucity of studies has considered whether EDC, including BPA, affects this behavior. To test whether early exposure to BPA and ethinyl estradiol (EE, estrogen present in birth control pills) results in metabolic and such behavioral disruptions, California mice developmentally exposed to BPA and EE were tested as adults for energy expenditure (indirect calorimetry), body composition (echoMRI) and physical activity (measured by beam breaks and voluntary wheel running). Serum glucose and metabolic hormones were measured. No differences in body weight or food consumption were detected. BPA-exposed females exhibited greater variation in weight than females in control and EE groups. During the dark and light cycles, BPA females exhibited a higher average respiratory quotient than control females, indicative of metabolizing carbohydrates rather than fats. Various assessments of voluntary physical activity in the home cage confirmed that during the dark cycle, BPA and EE-exposed females were significantly less active in this setting than control females. Similar effects were not observed in BPA or EE-exposed males. No significant differences were detected in serum glucose, insulin, adiponectin and leptin concentrations. Results suggest that females developmentally exposed to BPA exhibit decreased motivation to engage in voluntary physical activity and altered metabolism of carbohydrates v. fats, which could have important health implications.