Structure, functions, and evolution of the third complement component and viral molecular mimicry
Structure, functions, and evolution of the third complement component and viral molecular mimicry
复制标题
DOI：
10.1007/bf02786436
复制
发表时间：
1998-01-01
影响因子：
4.4
通讯作者：
Lambris, JD
中科院分区：
文献类型：
--
作者：
Sahu, A;Sunyer, JO;Lambris, JD
补体系统的第三个组成部分 C3 是激活经典途径、替代途径和凝集素途径的共同点。 C3 分子与至少 20 种不同蛋白质相互作用的能力使其成为该系统中最通用的组件。由于这些相互作用对于吞噬、免疫调节和免疫逃避机制很重要，因此对其结构和功能的分析一直是深入研究的课题。在这里，我们回顾了我们目前在 C3-配体相互作用、C3 相关病毒分子拟态、补体系统的进化以及基于 C3 的补体抑制剂的鉴定方面的工作。
The third component of the complement system, C3, is a common denominator in the activation of the classical, alternative, and lectin pathways. The ability of C3 molecule to interact with at least 20 different proteins makes it the most versatile component of this system. Since these interactions are important for phagocytic, immunoregulatory, and immune evasion mechanisms, the analysis of its structure and functions has been a subject of intense research. Here we review our current work on the C3-ligand interactions, C3-related viral molecular mimicry, evolution of the complement system, and identification of C3-based complement inhibitors.