Microbiota, oral microbiome, and pancreatic cancer.
Microbiota, oral microbiome, and pancreatic cancer.
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DOI：
10.1097/ppo.0000000000000046
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Izard J
中科院分区：
文献类型：
--
作者：
Michaud DS;Izard J
只有30%的胰腺癌患者在诊断后一年存活。在了解胰腺癌的病因方面已经取得了进展，包括巩固了与肥胖和糖尿病的联系，并且一部分病例应该通过改变生活方式来预防。不幸的是，确定早期胰腺癌的可靠生物标志物一直极具挑战性，目前还没有有效的筛查方式可用于这种毁灭性的癌症。最近的数据表明，微生物群可能在疾病过程中发挥作用，但仍存在许多问题。未来的研究重点是人类微生物组，无论是病原学上还是作为疾病易感性的标志，应该阐明如何更好地预防、早期发现和治疗这种高度致命的疾病。
Only 30% of patients diagnosed with pancreatic cancer survive one year post-diagnosis. Progress in understanding the causes of pancreatic cancer has been made, including solidifying the associations with obesity and diabetes, and a proportion of cases should be preventable through lifestyle modifications. Unfortunately, identifying reliable biomarkers of early pancreatic cancer has been extremely challenging, and no effective screening modality is currently available for this devastating form of cancer. Recent data suggest the microbiota may play a role in the disease process, but many questions remain. Future studies focusing on the human microbiome, both etiologically and as a marker of disease susceptibility, should shed light on how to better tackle prevention, early detection, and treatment of this highly fatal disease.