EFFECTIVE ARTERIAL ELASTANCE AS INDEX OF ARTERIAL VASCULAR LOAD IN HUMANS
EFFECTIVE ARTERIAL ELASTANCE AS INDEX OF ARTERIAL VASCULAR LOAD IN HUMANS
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DOI：
10.1161/01.cir.86.2.513
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发表时间：
1992-08-01
期刊：
影响因子：
37.8
通讯作者：
KASS, DA
中科院分区：
文献类型：
--
作者：
KELLY, RP;TING, CT;KASS, DA
背景本研究测试了心室收缩末期压与每搏输出量的简单比率（称为有效动脉弹性（E（a）））是否可以有效测量正常和老年高血压血管的动脉负荷。方法和结果。同时测定了10例受试者（4例年轻血压正常，6例老年高血压）的心室压力-容积和有创主动脉压力和流量。在休息时，在机械减少前负荷，并在药物干预后获得测量。比较了动脉负荷的两种测量方法：一种是使用基于动脉系统三要素Windkessel模型的代数表达式[E（a）（Z）]从主动脉输入阻抗和动脉顺应性数据导出的，另一种更简单地测量为心室收缩末期压与每搏输出量的比值[E（a）（PV）]。尽管E（a）（PV）是从完全不同的数据来源得出的，尽管E（a）（PV）的假设是简化的，但E（a）（Z）和E（a）（PV）在很大范围的改变条件下实际上是相同的：E（a）（PV）= 0.97。E（a）（Z）+0.17; n=33，r2=0.98，SEE=0.09，p
Background. This study tested whether the simple ratio of ventricular end-systolic pressure to stroke volume, known as the effective arterial elastance (E(a)), provides a valid measure of arterial load in humans with normal and aged hypertensive vasculatures.Methods and Results. Ventricular pressure-volume and invasive aortic pressure and flow were simultaneously determined in 10 subjects (four young normotensive and six older hypertensive). Measurements were obtained at rest, during mechanically reduced preload, and after pharmacological interventions. Two measures of arterial load were compared: One was derived from aortic input impedance and arterial compliance data using an algebraic expression based on a three-element Windkessel model of the arterial system [E(a)(Z)], and the other was more simply measured as the ratio of ventricular end-systolic pressure to stroke volume [E(a)(PV)]. Although derived from completely different data sources and despite the simplifying assumptions of E(a)(PV), both E(a)(Z) and E(a)(PV) were virtually identical over a broad range of altered conditions: E(a)(PV) = 0.97 . E(a)(Z) +0.17; n=33, r2=0.98, SEE=0.09, p